DIAGNOSTIC IMAGING OF CRANIOSYNOSTOSES

三维计算机断层扫描（3DCT）的主要应用领域 是头部成像。 3DCT在确定 先天性和后天性颅面畸形的存在和程度。 本提案的目的是比较敏感性和 3DCT图像在检测和表征 颅缝早闭与平面CT和常规头颅X线检查的关系， 具体说明观察员的经验在解释 这些基于图像的诊断 200名患者（100名患者和100名患者） 无骨性结合的患者将进行CT、3DCT和头颅X线平片成像。 将测试成像模式和观察者经验水平， ROC分析有显著性差异。 我们假设3DCT是 明显优于其他成像系统， 颅缝早闭与3DCT：观察者经验重要性 将大大减少。

A major area of application of three dimensional computed tomography (3DCT) is imaging of the head. 3DCT has an important role in determining the presence and extent of congenital and acquired craniofacial deformities. The objectives of this proposal are to compare the sensitivity and specificity of 3DCT images in the detection and characterization of craniosynostosis with that of planar CT and routine skull x-rays and to specify the role played by observer experience in the interpretation of these image-based diagnoses. Two hundred patients (100 with and 100 without synostoses will be imaged with CT, 3DCT, and plain skull x-rays. Imaging modalities and levels of observer experience will be tested for significant differences with ROC analysis. We hypothesize that 3DCT is significantly better than other imaging systems for the delineation of craniosynostosis and that for 3DCT the importance of observer experience will be significantly less.