REGULATION OF THYROID FUNCTION T4 AND T3 KINETICS

甲状腺功能 T4 和 T3 动力学的调节

• 批准号: 3226220
• 负责人: Lewis Braverman
• 金额: $ 26.06万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3226220
• 关键词: autoimmune disorder; embryo /fetus; endocrine disorder chemotherapy; hormone metabolism; hormone regulation /control mechanism; human subject; hyperthyroidism; hypothyroidism; immunosuppressive; iodination; lithium; lymphomatous thyroiditis; neurotensin; newborn animals; nutrition related tag; pituitary thyroid axis; placental transfer; radiotracer; thyroid function; thyroid inhibitor; thyrotropin; triiodothyronine

The proposed studies are a continuation of the principal investigator's research interests in 5 areas: 1. the peripheral metabolism of the thyroid hormones especially the physiologic role of the human and rodent placenta in modulating the transplacental passage of the thyroid hormones in vivo and the nutritional control of TBG generation and the deiodination of the iodothyronines in the lean and genetically obese Zucker rat; 2. the use of 125I-Triac as a probe to quantitate the T3 nuclear receptor in rat tissues and human peripheral lymphocytes under a variety of abnormal thyroid and non-thyroid states; 3. the interrelationship between two neuropeptides (neurotensin (NT) and substance P (SP) and a recently described potent endogenous opioid peptide (dermorphin) with TRH and the thyroid hormones in the control of TSH secretion in vivo by hypothalamic microinjections of NT, SP and dermorphin and in vitro using pituitary and hypothalamic fragments; 4. the effect of excess iodide on thyroid function in patients receiving amiodarone and lithium and in the spontaneous diabetic BB/W rat who develops autoimmune lymphocytic thyroiditis (LT; 5. attempts will be made to enhance or attenuate LT in the BB/W rat with transferred or spontaneous diabetes mellitus by low or high iodine intake and the administration of methimazole which appears to be an immunosuppressant of the thyroid lymphocyte. These efforts should further our understanding of the regulation of adult and fetal thyroid function under normal and pathological conditions and are directly related to previous and present activities in our laboratory.

拟定的研究是主要研究者 研究兴趣在5个方面：1. 外周代谢 甲状腺激素，特别是人类和啮齿动物的生理作用 胎盘在调节甲状腺激素经胎盘传递中的作用 在体内和营养控制TBG的产生和脱碘 在瘦的和遗传肥胖的Zucker大鼠中的碘甲腺原氨酸; 2. 的 用~（125）I-Triac作为探针定量测定大鼠T_3核受体 组织和人外周血淋巴细胞在各种异常 甲状腺和非甲状腺状态; 3. 两者之间的相互关系 神经肽（神经降压素（NT）和P物质（SP））以及近年来发现的一种新的神经肽 描述了有效的内源性阿片肽（皮吗啡）与TRH和 甲状腺激素对下丘脑促甲状腺激素分泌的调节作用 微量注射NT、SP和dermorphin， 下丘脑碎片; 4. 过量碘对甲状腺功能的影响 在接受胺碘酮和锂的患者中， 糖尿病BB/W大鼠发生自身免疫性淋巴细胞性甲状腺炎（LT; 5. 将尝试增强或减弱BB/W大鼠中的LT， 低碘或高碘摄入引起的转移性或自发性糖尿病 以及甲巯咪唑的给药， 甲状腺淋巴细胞的免疫抑制剂。 这些努力应进一步 我们对成人和胎儿甲状腺功能调节的理解 在正常和病理条件下， 我们实验室以前和现在的活动。