REGULATION OF THYROID FUNCTION T4 AND T3 KINETICS

甲状腺功能 T4 和 T3 动力学的调节

• 批准号: 3226221
• 负责人: Lewis Braverman
• 金额: $ 26.2万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3226221
• 关键词: amiodarone; autoimmune disorder; embryo /fetus; endocrine disorder chemotherapy; guinea pigs; hormone metabolism; hormone receptor; hormone regulation /control mechanism; human subject; hyperthyroidism; hypothyroidism; immunosuppressive; insulin dependent diabetes mellitus; iodination; laboratory rat; lithium; lymphomatous thyroiditis; neuropeptides; neurotensin; newborn animals; nutrition related tag; pituitary thyroid axis; placental transfer; radiotracer; substance P; thyroid function; thyroid hormone binding protein; thyroid inhibitor; thyrotropin; triiodothyronine

The proposed studies are a continuation of the principal investigator's research interests in 5 areas: 1. the peripheral metabolism of the thyroid hormones especially the physiologic role of the human and rodent placenta in modulating the transplacental passage of the thyroid hormones in vivo and the nutritional control of TBG generation and the deiodination of the iodothyronines in the lean and genetically obese Zucker rat; 2. the use of 125I-Triac as a probe to quantitate the T3 nuclear receptor in rat tissues and human peripheral lymphocytes under a variety of abnormal thyroid and non-thyroid states; 3. the interrelationship between two neuropeptides (neurotensin (NT) and substance P (SP) and a recently described potent endogenous opioid peptide (dermorphin) with TRH and the thyroid hormones in the control of TSH secretion in vivo by hypothalamic microinjections of NT, SP and dermorphin and in vitro using pituitary and hypothalamic fragments; 4. the effect of excess iodide on thyroid function in patients receiving amiodarone and lithium and in the spontaneous diabetic BB/W rat who develops autoimmune lymphocytic thyroiditis (LT; 5. attempts will be made to enhance or attenuate LT in the BB/W rat with transferred or spontaneous diabetes mellitus by low or high iodine intake and the administration of methimazole which appears to be an immunosuppressant of the thyroid lymphocyte. These efforts should further our understanding of the regulation of adult and fetal thyroid function under normal and pathological conditions and are directly related to previous and present activities in our laboratory.

拟议的研究是主要研究者的延续 研究兴趣有5个领域： 1. 外周代谢 甲状腺激素尤其是人类和啮齿动物的生理作用 胎盘调节甲状腺激素经胎盘的通道 TBG生成和脱碘的体内和营养控制 瘦和遗传性肥胖 Zucker 大鼠中碘甲状腺原氨酸的变化； 2. 的 使用 125I-Triac 作为探针定量大鼠 T3 核受体 各种异常情况下的组织和人外周淋巴细胞 甲状腺和非甲状腺状态； 3. 两者之间的关系 神经肽（神经降压素 (NT) 和 P 物质 (SP) 以及最近的一种 描述了有效的内源性阿片肽（dermorphin）与 TRH 和 甲状腺激素通过下丘脑控制体内 TSH 分泌 NT、SP 和 dermorphin 的显微注射以及体外使用垂体和 下丘脑碎片； 4、过量碘对甲状腺功能的影响 接受胺碘酮和锂治疗的患者以及自发性 患有自身免疫性淋巴细胞甲状腺炎的糖尿病 BB/W 大鼠（LT；5. 将尝试增强或减弱 BB/W 大鼠的 LT 由低或高碘摄入引起的转移性或自发性糖尿病 以及服用甲硫咪唑，这似乎是一种 甲状腺淋巴细胞的免疫抑制剂。 这些努力应该进一步 我们对成人和胎儿甲状腺功能调节的理解 在正常和病理条件下，与 我们实验室以前和现在的活动。