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Effect of prolonged inactivity on vestibular control of balance

长时间不活动对前庭平衡控制的影响

基本信息

批准号：
BB/P017185/1
负责人：
Raymond Reynolds
金额：
$ 8.99万
依托单位：
University of Birmingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FP017185%2F1
关键词：
Effect prolonged inactivity vestibular control

项目摘要

Postural instability and falls are a major problem in older adults, leading to injuries and increased mortality. Understanding the precise cause(s) of instability is necessary before we can implement targeted therapy programmes or lifestyle changes. One factor known to exacerbate instability and fall risk is inactivity, which tends to increase with age. This tendency towards inactivity is compounded by age-related morbidity, which often results in extended periods of profound inactivity, either in the home or in a hospital bed. Although such inactivity is known to impair postural control, we do not understand the precise mechanisms. The purpose of this project is to examine the effect of prolonged inactivity upon postural control. We will study young healthy subjects before and after a prolonged period of bed rest (60 days). By studying young adults, we will gain a pure understanding of how inactivity affects posture without the confounding co-morbidities associated with age. We will assess postural control using a technique called galvanic vestibular stimulation (GVS). GVS causes a sway response in standing subjects and can be used to test the efficacy of the balance system. We will examine GVS responses immediately before and after prolonged bed rest to determine how the response changes. The amplitude and accuracy of the sway response will be analysed separately. Any reduction in amplitude, or variability in the directional accuracy of the response, would indicate impaired postural control. Identifying such problems will provide therapeutic targets for recovery of postural control following inactivity.

姿势不稳定和跌倒是老年人的一个主要问题，导致受伤和死亡率增加。在我们实施有针对性的治疗计划或改变生活方式之前，有必要了解不稳定的确切原因。已知会加剧不稳定和跌倒风险的因素之一是缺乏活动，这种情况往往会随着年龄的增长而增加。这种不活动的倾向因与年龄相关的发病率而变得更加复杂，这通常会导致长时间的严重不活动，无论是在家里还是在医院的病床上。尽管已知这种不活动会损害姿势控制，但我们不了解确切的机制。该项目的目的是检查长时间不活动对姿势控制的影响。我们将研究年轻健康受试者长期卧床休息（60 天）前后的情况。通过研究年轻人，我们将获得对缺乏活动如何影响姿势的纯粹理解，而不会出现与年龄相关的混杂共病。我们将使用一种称为前庭电流刺激 (GVS) 的技术来评估姿势控制。 GVS 会引起站立受试者的摇摆反应，可用于测试平衡系统的功效。我们将在长时间卧床休息之前和之后立即检查 GVS 反应，以确定反应如何变化。摇摆响应的幅度和精度将分别进行分析。任何幅度的减小或响应方向精度的变化都表明姿势控制受损。识别这些问题将为恢复不活动后的姿势控制提供治疗目标。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Intrinsic ankle stiffness during standing increases with ankle torque and passive stretch of the Achilles tendon.

DOI：
10.1371/journal.pone.0193850
发表时间：
2018
期刊：
PloS one
影响因子：
3.7
作者：
Sakanaka TE;Gill J;Lakie MD;Reynolds RF
通讯作者：
Reynolds RF

Differential effects of vision upon the accuracy and precision of vestibular-evoked balance responses.

DOI：
10.1113/jp275645
发表时间：
2018-06
期刊：
The Journal of physiology
影响因子：
0
作者：
Mackenzie SW;Reynolds RF
通讯作者：
Reynolds RF

Where's your head at? An illusion of head orientation which reveals dissociation of proprioceptive signals for balance versus perception

你的头在哪里？

DOI：
10.1113/jp273874
发表时间：
2017
期刊：
The Journal of Physiology
影响因子：
0
作者：
Reynolds R
通讯作者：
Reynolds R

Ocular torsion responses to electrical vestibular stimulation in vestibular schwannoma.

DOI：
10.1016/j.clinph.2018.08.023
发表时间：
2018-11
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
0
作者：
Mackenzie SW;Irving R;Monksfield P;Kumar R;Dezso A;Reynolds RF
通讯作者：
Reynolds RF

Ocular torsion responses to sinusoidal electrical vestibular stimulation.

眼扭转对正弦电的前庭刺激的反应。