REGULATION OF GLOMERULAR AND PROXIMAL NEPHRON FUNCTION

该项目的目标是确定是否有一个髓质肾单位， 肾脏表现出对它们的肾小球速率施加反馈控制的能力， 过滤 在一系列开环反馈实验中， 反馈将被测量在延髓和浅表肾单位， 水肿和利尿仓鼠肾。 汉勒袢灌注的效果 在相同的肾单位中，滤过率和灌注液成分对滤过率的影响将是 测定了 在一系列闭环反馈实验中， 确定肾小管-肾小球反馈是否介导肾小管-髓质肾单位 肾小球滤过率的自动调节。 通过测量延髓 肾单位滤过率而不中断肾小管肾小球机制 在利尿期间的反馈，将确定是否增加亨利环 利尿引起的血流导致单个肾单位滤过率降低 通过激活髓质肾单位小管肾小球反馈。 一个组成 研究的一部分是亨利环函数的数学模型。 的 模型，刺激循环水和溶质重吸收，用于 实验设计和数据解释。

The goal of the project is to determine whether juxtamedullary nephrons of the kidney exhibit the ability to exert feedback control on their rate of glomerular filtration. In a series of open-feedback-loop experiments, tubuloglomerular feedback will be measured in juxtamedullary and superficial nephrons in hydropenic and diuretic hamster kidneys. The effects of Henle's loop perfusion rate and perfusate composition on filtration rate in the same nephron will be measured. In a series of closed-feedback-loop experiments, it will be determined whether tubuloglomerular feedback mediates juxtamedullary nephron autoregulation of glomerular filtration rate. By measuring juxtamedullary nephron filtration rate without interrupting the mechanism of tubuloglomerular feedback during diuresis, it will be determined if the increased loop of Henle flow due to the diuresis leads to a reduction in single nephron filtration rate by activating juxtamedullary nephron tubuloglomerular feedback. An integral part of the research is a mathematical model of Henle's loop function. The model, which stimulates loop water and solute reabsorption, is used for experimental design and data interpretation.