TC-99M NGA IN THE EVALUATION OF LIVER DISEASE

我们研究的长期目标是确定TcNGA的作用 肝功能参数估计及其与肝脏的关系 从诊断和预后的角度来看。 我们计划 评估TcNGA作为肝脏定量测量的有用性 在四个方面发挥作用：1）肝病预后，2）治疗 对肝脏疾病的影响，3）疾病存在和疾病分类 类别，和4）区域与整体肝功能估计。 目标1、2和3将使用现代统计分析来实现。 使用考克斯回归模型， 也可以获得肝病的预后和治疗效果， 作为治疗依赖性预后的更精确估计， 个别患者。 利用判别分析方法， 疾病的存在和疾病的类别。 目标4是使用平面、SPECT和PET NGA进行初步评价 成像技术。 这将解决区域是否 肝功能的估计增加了显著的预后或治疗 信息. 它还将解决PET的优点和缺点 对比SPECT对比平面NGA动力学建模。 此外，14 C-氨基比林呼气试验和内源性配体 将进行分析，如果可能，我们将获得肝脏并进行分析 用于测定肝结合蛋白浓度的活检样品。 这些值将与NGA功能参数相关 估算

The long term goal of our research is to determine the role of TcNGA parameter estimates of liver function and their relationship to liver disease, both from a diagnostic and prognostic viewpoint. We plan to evaluate the usefulness of TcNGA as a quantitative measure of liver function in four areas: 1) prognosis in liver disease, 2) therapeutic effect in liver disease, 3) classification of disease presence and disease category, and 4) regional versus global estimation of liver function. Aims, 1, 2 and 3 will be accomplished using modern statistical analysis. Using the Cox regression models, information on variables associated with prognosis and therapeutic effect in liver disease can be obtained, as well as a more precise estimation of therapy-dependent prognosis in the individual patient. With the discriminant analysis method, classification of disease presence and disease category can be accomplished. Aim 4 will be a preliminary evaluation using planar, SPECT, and PET NGA imaging techniques. This will address the question of whether regional estimates of liver function add significant prognostic or therapeutic information. It will also address the advantages and disadvantages of PET versus SPECT versus planar NGA kinetic modeling. In addition, the 14C-aminopyrine breath test and the endogenous ligand assay will be performed, and when possible, we will obtain and assay liver biopsy samples for determination of hepatic binding protein concentration. These values will be correlated with the NGA functional parameter estimates.