TC99M-NEOGALACTOALBUMIN EVALUATION OF LIVER DISEASE

TC99M-新半乳糖白蛋白 肝脏疾病评估

• 批准号: 3232963
• 负责人: ROBERT CHARLES STADALNIK
• 金额: $ 11.99万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3232963
• 关键词: galactose; human subject; image processing; indocyanine green; liver cells; liver disorder diagnosis; prognosis; radionuclide diagnosis; radiopharmacology; technetium

Our aim is to compare the estimates of hepatic blood flow and functional hepatocyte mass using Tc-99m-neogalactoalbumin (Tc-NGA) to standard diagnostic modalities currently employed and to evaluate the prognostic usefulness in various hepatocellular disease states. Tc-99m-NGA enables one to obtain anatomic images as well as information on blood flow and functional hepatocyte mass. In the first year, images obtained with Tc-99m-NGA will be compared to CT, ultrasound, liver biopsy results, and radionuclide images obtained with Tc-99m sulfur colloid and Tc-99m disofenin. Estimates of liver blood flow using Tc-99m-NGA will be compared to simultaneous indocyanine green and galactose clearance blood flow determinations. Functional hepatocyte mass estimates obtained using Tc-99m-NGA will be compared to measurements of functional mass obtained by aminopyrine breath test (ABT) clearance studies. In addition to these modalities, biochemical and physiological data obtained during routine clinical evaluations will be compared to the results obtained with Tc-99m-NGA. In the second year, serial studies using Tc-NGA and ABT will be obtained with a limited number of patients in selected categories of hepatocellular disease. Tc-NGA functional imaging may provide a reliable estimate of quantitative change in hepatocellular function as well as provide an indicator of prognosis.

我们的目的是比较肝血流量和功能的估计 使用Tc-99 m-新半乳糖白蛋白（Tc-NGA）测定肝细胞质量，以标准 目前采用的诊断方式，并评估预后 适用于各种肝细胞疾病状态。 Tc-99 m-NGA使 一个用于获得解剖图像以及关于血流的信息， 功能性肝细胞质量。 在第一年，使用Tc-99 m-NGA获得的图像将与CT进行比较， 超声、肝活检结果和放射性核素图像， Tc-99 m硫胶体和Tc-99 m地索芬。 肝血流量估计值 将使用Tc-99 m-NGA与同时使用吲哚菁绿色和 半乳糖清除率血流测定。 功能性肝细胞质量 使用Tc-99 m-NGA获得的估计值将与 通过氨基比林呼吸试验（ABT）清除获得的功能性质量 问题研究 除了这些方式，生物化学和生理学 将常规临床评价期间获得的数据与 用Tc-99 m-NGA获得的结果。 在第二年，将获得使用Tc-NGA和ABT的系列研究 在选定的肝细胞癌类别中， 疾病 Tc-NGA功能成像可以提供可靠的估计， 肝细胞功能的定量变化以及提供 预后指标。