COLLABORATIVE STUDIES OF PEDIATRIC RENAL DISEASE

小儿肾脏疾病的合作研究

• 批准号: 3231288
• 负责人: BILLY S ARANT
• 金额: $ 9.11万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-30 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3231288
• 关键词: child (0-11); human subject; kidney disorder

The aims of this program project from the Southwest Pediatric Nephrology Study Group are: 1) to define the clinical course of a series of poorly understood renal disorders in children and to undertake prospective therapeutic trials in these disorders where appropriate; 2) to study the complications of chronic, progressive renal insufficiency in childhood; and 3) to evaluate methods of treatment for end-stage renal disease (ESRD) in childhood. These aims will be achieved by multicenter collaborative studies in the 10 centers listed in this proposal. The overall goal of our proposal will be to increase knowledge of different stages of renal disease; this will be achieved by the following specific studies: 1) Study of the clinical course and evaluation of clinco-pathologic correlations in a) idiopathic IgA nephropathy (Berger's Disease); b) nephrotic syndrome associated with diffuse mesangial hypercellularity; c) nephrotic syndrome associated with focal segmental glomerulosclerosis; d) membranous glomerulonephropathy; e) membrano-proliferative glomerulonephritis; f) mild or moderate vesico-ureteric reflux; and g) idiopathic hypercalciuria associated with hematuria. A prospective trial of intravenous high-dose methylprednisolone and oral prednisone in proliferative glomerulonephritis associated with systemic lupus erythematosus will also be undertaken. 2) The following inter-related complications of chronic progressive renal insufficiency will be studied: a) nutrition; b) renal osteodystrophy; c) anemia; and d) growth. 3) The main focus of our studies of childhood ESRD will be the evaluation of methods of prolonged dwell peritoneal dialysis (CAPD and CCPD). Technical aspects (e.g.: catheter problems, peritonitis) of these modalities will be assessed, and the effects of each treatment on nutrition, renal osteodystrophy, anemia and growth will be studied. The documented close cooperation of the centers listed in this proposal will enable the studies to be conducted in an efficient and scientifically accurate manner such that in the next five years we will obtain answers to many of the questions existing today in Pediatric Nephrology.

西南儿科肾脏病学项目的目标 研究小组有：1）定义一系列不良的临床过程 了解儿童肾脏疾病并进行前瞻性研究 适当时对这些疾病进行治疗试验； 2）研究 儿童期慢性进行性肾功能不全的并发症；和 3）评估终末期肾病（ESRD）的治疗方法 童年。 这些目标将通过多中心协作来实现 在本提案中列出的 10 个中心进行研究。 我们的总体目标 建议增加对肾病不同阶段的了解 疾病;这将通过以下具体研究来实现：1）研究 临床病程的分析和临床病理相关性的评估 a) 特发性 IgA 肾病（伯杰病）； b) 肾病综合征 与弥漫性系膜细胞增多有关； c) 肾病综合征 与局灶节段性肾小球硬化有关； d) 膜状 肾小球肾病; e) 膜增生性肾小球肾炎； f) 温和 或中度膀胱输尿管反流； g) 特发性高钙尿症 与血尿有关。 静脉高剂量注射的前瞻性试验 甲基泼尼松龙和口服泼尼松治疗增殖性肾小球肾炎 与系统性红斑狼疮相关的检查也将进行。 2） 慢性进行性肾病的以下相互关联的并发症 将研究以下不足： a) 营养； b) 肾性骨营养不良； c) 贫血; d) 增长。 3）我们对儿童ESRD研究的主要焦点 将评估延长腹膜透析的方法 （CAPD 和 CCPD）。 技术方面（例如：导管问题、腹膜炎） 将评估这些方式，以及每种治疗的效果 将研究营养、肾性骨营养不良、贫血和生长。 本提案中列出的各中心的密切合作记录在案 使研究能够高效、科学地进行 准确的方式，以便在未来五年内我们将获得以下问题的答案 当今儿科肾脏病学中存在的许多问题。