COLLABORATIVE STUDIES OF PEDIATRIC RENAL DISEASE

该项目的目的是从西南儿科肾病 研究组主要有：1）明确一系列临床病程不佳 了解儿童肾脏疾病，并进行前瞻性 在适当的情况下，对这些疾病进行治疗试验; 2）研究 儿童期慢性进行性肾功能不全并发症;以及 3)评价终末期肾病（ESRD）的治疗方法， 童年. 这些目标将通过多中心合作实现 本提案中列出的10个中心的研究。 我们的总体目标是 建议将增加知识的不同阶段的肾 疾病;这将通过以下具体研究实现：1）研究 的临床过程和临床病理相关性的评价， a）特发性伊加肾病（伯杰病）; B）肾病综合征 与弥漫性系膜细胞过多相关; c）肾病综合征 与局灶节段性肾小球硬化相关; d）膜性 肾小球肾病; e）膜增生性肾小球肾炎; f）轻度 或中度膀胱输尿管反流;和g）特发性高钙尿症 与血尿有关。 大剂量静脉给药的前瞻性试验 甲基强的松龙和口服强的松治疗增生性肾小球肾炎 与系统性红斑狼疮相关的疾病也将进行。 （二） 慢性进展性肾功能衰竭的相关并发症 将研究以下方面：a）营养; B）肾性骨营养不良; c） 贫血;和d）生长。 3)我们对儿童ESRD研究的主要焦点是 将对长期留置腹膜透析的方法进行评价 (CAPD CCPD）。 技术方面（例如： 导管问题、腹膜炎） 将评估这些模式，以及每种治疗对 将研究营养、肾性骨营养不良、贫血和生长。 本建议书中所列中心的密切合作记录 将使研究能够以有效和科学的方式进行， 在未来的五年里，我们将获得答案， 目前儿科肾病学中存在的许多问题。

The aims of this program project from the Southwest Pediatric Nephrology Study Group are: 1) to define the clinical course of a series of poorly understood renal disorders in children and to undertake prospective therapeutic trials in these disorders where appropriate; 2) to study the complications of chronic, progressive renal insufficiency in childhood; and 3) to evaluate methods of treatment for end-stage renal disease (ESRD) in childhood. These aims will be achieved by multicenter collaborative studies in the 10 centers listed in this proposal. The overall goal of our proposal will be to increase knowledge of different stages of renal disease; this will be achieved by the following specific studies: 1) Study of the clinical course and evaluation of clinco-pathologic correlations in a) idiopathic IgA nephropathy (Berger's Disease); b) nephrotic syndrome associated with diffuse mesangial hypercellularity; c) nephrotic syndrome associated with focal segmental glomerulosclerosis; d) membranous glomerulonephropathy; e) membrano-proliferative glomerulonephritis; f) mild or moderate vesico-ureteric reflux; and g) idiopathic hypercalciuria associated with hematuria. A prospective trial of intravenous high-dose methylprednisolone and oral prednisone in proliferative glomerulonephritis associated with systemic lupus erythematosus will also be undertaken. 2) The following inter-related complications of chronic progressive renal insufficiency will be studied: a) nutrition; b) renal osteodystrophy; c) anemia; and d) growth. 3) The main focus of our studies of childhood ESRD will be the evaluation of methods of prolonged dwell peritoneal dialysis (CAPD and CCPD). Technical aspects (e.g.: catheter problems, peritonitis) of these modalities will be assessed, and the effects of each treatment on nutrition, renal osteodystrophy, anemia and growth will be studied. The documented close cooperation of the centers listed in this proposal will enable the studies to be conducted in an efficient and scientifically accurate manner such that in the next five years we will obtain answers to many of the questions existing today in Pediatric Nephrology.