COLLABORATIVE STUDIES OF PEDIATRIC RENAL DISEASE

小儿肾脏疾病的合作研究

• 批准号: 3231289
• 负责人: BILLY S ARANT
• 金额: $ 9.1万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-30 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3231289
• 关键词: child (0-11); chronic renal failure; human subject; kidney disorder

The aims of this program project from the Southwest Pediatric Nephrology Study Group are: 1) to define the clinical course of a series of poorly understood renal disorders in children and to undertake prospective therapeutic trials in these disorders where appropriate; 2) to study the complications of chronic, progressive renal insufficiency in childhood; and 3) to evaluate methods of treatment for end-stage renal disease (ESRD) in childhood. These aims will be achieved by multicenter collaborative studies in the 10 centers listed in this proposal. The overall goal of our proposal will be to increase knowledge of different stages of renal disease; this will be achieved by the following specific studies: 1) Study of the clinical course and evaluation of clinco-pathologic correlations in a) idiopathic IgA nephropathy (Berger's Disease); b) nephrotic syndrome associated with diffuse mesangial hypercellularity; c) nephrotic syndrome associated with focal segmental glomerulosclerosis; d) membranous glomerulonephropathy; e) membrano-proliferative glomerulonephritis; f) mild or moderate vesico-ureteric reflux; and g) idiopathic hypercalciuria associated with hematuria. A prospective trial of intravenous high-dose methylprednisolone and oral prednisone in proliferative glomerulonephritis associated with systemic lupus erythematosus will also be undertaken. 2) The following inter-related complications of chronic progressive renal insufficiency will be studied: a) nutrition; b) renal osteodystrophy; c) anemia; and d) growth. 3) The main focus of our studies of childhood ESRD will be the evaluation of methods of prolonged dwell peritoneal dialysis (CAPD and CCPD). Technical aspects (e.g.: catheter problems, peritonitis) of these modalities will be assessed, and the effects of each treatment on nutrition, renal osteodystrophy, anemia and growth will be studied. The documented close cooperation of the centers listed in this proposal will enable the studies to be conducted in an efficient and scientifically accurate manner such that in the next five years we will obtain answers to many of the questions existing today in Pediatric Nephrology.

《西南儿科肾病》项目的目标 研究组有：1)明确一系列临床病程不佳 了解儿童肾脏疾病并进行前瞻性研究 在适当的情况下对这些疾病进行治疗试验；2)研究 儿童时期慢性进行性肾功能不全的并发症； 3)评价我国终末期肾病的治疗方法。 童年。这些目标将通过多中心协作实现 在本提案中列出的10个中心进行研究。我们的总体目标是 建议是增加对肾脏不同阶段的了解 疾病；这将通过以下具体研究来实现：1)研究 临床病程与临床病理对照的评价 A)特发性IgA肾病(伯格氏病)；b)肾病综合征 与弥漫性系膜细胞增多症有关；c)肾病综合征 与局灶节段性肾小球硬化有关；d)膜性 肾小球肾炎；e)膜增生性肾小球肾炎；f)轻度 或中度膀胱输尿管反流；和g)特发性高钙尿 与血尿有关。静脉大剂量给药的前瞻性试验 甲基强的松龙与口服强的松治疗增生性肾小球肾炎 与系统性红斑狼疮相关的也将进行。2) 慢性进展性肾脏病的下列相关并发症 将研究：a)营养不足；b)肾性骨营养不良；c) 贫血；和d)生长。3)儿童ESRD研究的主要焦点 将对延长滞留腹膜透析的方法进行评估 (CAPD和CCPD)。技术方面(例如：导管问题、腹膜炎) 将对这些模式进行评估，以及每种治疗方法对 营养、肾性骨营养不良、贫血和生长将被研究。 本建议书中所列中心的密切合作文件 将使研究能够以高效和科学的方式进行 准确的方式，以便在未来五年内，我们将获得关于 儿科肾脏病目前存在的许多问题。