CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE

健康和疾病中结肠运动的控制

• 批准号: 3230793
• 负责人: SUSHIL K SARNA
• 金额: $ 10.05万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-04-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3230793
• 关键词: cholecystokinin; colon; colonic diverticulosis; computer data analysis; constipation; denervation; diarrhea; dietary fiber; electrophysiology; electrostimulus; ganglionic blocking agents; gastrointestinal motility /pressure; gastrointestinal pharmacology; hormone regulation /control mechanism; human subject; innervation; intestine obstruction; irritable bowel syndrome; morphine; muscle contraction; nutrition related tag; opiate alkaloid; parasympathetic nervous system; peptide hormone; vagotomy

The overall objective of this research proposal is to elucidate the myogenic, neural and hormonal control mechanisms for the control of colonic motor function in health and disease. Particular emphasis is laid on the cyclic motor and myoelectrical activities in the colon, the mechanisms of intiation and propagation of these cyclic activities, the effects of control, low fiber and high fiber diets on these activities, the coupling between colonic electrical and contractile activities, and the effects of some selected pharmacologic agents and peptides on colonic electrical and contractile activities. The experiments will be done on conscious and anesthetized dogs using implanted strain gauges and electrodes and on humans using intraluminal recording tubes mounted with suction cup electrodes and strain gauge elements. The role of nerves in the control of colonic motility will be studied by the techniques of nerve section and electrical stimulation of nerves. The coupling between electrical and contractile activities and the effect of pharmacological agents will be studied by close intraarterial perfusions and systemic administrations. The data will be analysed by computer and/or electronic filtering and visually. Our long term goal is to apply the knowledge and understanding obtained from animal experiments to the study of human colonic motor function in health and in various pathological states such as irritable bowel syndrome, idiopathic intestinal pseudoobstruction, and diverticular disease. An insight into the functioning of the myogenic, neural and hormonal control mechanisms in health and in colonic motility disorders will be essential to propose appropriate pharmacological, therapeutical and surgical measures to normalize colonic motor function in disease.

本研究提案的总体目标是阐明 用于控制结肠炎的肌源性、神经和激素控制机制 健康和疾病中的运动功能。 特别强调的是 结肠的周期性运动和肌电活动， 这些循环活动的启动和传播， 对照、低纤维和高纤维日粮对这些活性的影响， 结肠电活动和收缩活动之间的关系，以及 一些选定的药理学试剂和肽对结肠电和 收缩活动。 实验将在清醒和麻醉的狗身上进行， 植入的应变计和电极以及使用管腔内 安装有吸盘电极和应变计的记录管 元素 神经在控制结肠运动中的作用将是 通过神经切片和电刺激技术， 神经 电活动和收缩活动之间的耦合， 药理学试剂作用将通过闭合动脉内 灌注和全身给药。 数据将由 计算机和/或电子过滤和视觉。 我们的长期目标是应用所获得的知识和理解 从动物实验到人类结肠运动功能的研究， 健康和各种病理状态如肠易激综合征， 特发性假性肠梗阻和憩室病。 一个 深入了解肌源性、神经和激素控制的功能 健康和结肠动力障碍的机制将是必不可少的， 提出适当的药理、治疗和手术措施， 使疾病中的结肠运动功能正常化。