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PORTASYSTEMIC SHUNT QUANTITATION WITH RADIOACTIVE TRACER

使用放射性示踪剂进行门静脉分流定量

基本信息

批准号：
3234713
负责人：
CHI-KWAN YEN
金额：
$ 9.41万
依托单位：
MEDICAL RESEARCH INSTITUTE OF SAN FRAN
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
起止时间：
1987-10-01 至 1991-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3234713
关键词：
alcoholism /alcohol abuse amphetamines dogs liver cirrhosis noninvasive diagnosis portal hypertension radiotracer

项目摘要

The specific aim of this proposal is to develop and validate a noninvasive, rapid and quantitative method of measuring portasystemic shunting (PSS) in dogs with either spontaneous PSS or induced cirrhosis. The method will involve external monitoring of the kinetics of a radioactive tracer, I-123 labeled iodoamphetamine (IMP), after transrectal administration into the colon. Preliminary studies indicate that this method accurately quantifies PSS in animals with surgically created shunts. The applicability of this method will be evaluated in cirrhotic animals, and validated against the proven standard of microspheres method. This method will be used to determine whether the level of PSS has prognostic value in dogs with spontaneous PSS, and whether administration of beta blockers affects the level of PSS. The goal of this project is to evaluate whether a rational treatment, based on the measurement of PSS, can be developed for patients with portal hypertension. In the United States, most cases of portal hypertension are caused by alcoholic cirrhosis. The complications of portal hypertension are the major causes of mortality and morbidity in alcoholics. While a number of therapies have been successful in treating selected groups of patients, definitive benefits in all patients have not been demonstrated. This may be due to the lack of an objective indicator of favorable response to the different therapies. The basic abnormality in cirrhosis is mechanical obstruction of portal blood flow, resulting in portal hypertension and PSS. A hepatic encephalopathy and probably survival. In all patients treated with beta blockers for variceal bleeding, PSS is decreased to various degrees while other portal hemodynamic parameters respond unpredictably. Therefore, the degree of PSS response to beta blocker may be an important indicator of whether the patients are likely to benefit from this form of therapy. The level of PSS reflects the total amount of variceal blook flow and is probably related to both the variceal size and the likelihood of variceal bleeding. The level of PSS may therefore be an important prognostic indicator. For these reasons, PSS is potentially important in patient management. The development of an accurate, noninvasive and reproducible method for its measurement under different conditions is warranted.

本提案的具体目的是开发和验证一个

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Portasystemic shunt fraction quantification using transrectal administration of iodine-123 iodoamphetamine in dogs with chronic bile duct ligation and after propranolol administration.

在慢性胆管结扎犬和普萘洛尔给药后，使用经直肠给药碘 123 碘苯丙胺进行门体分流分数定量。

DOI：
发表时间：
1989
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
0
作者：
Yen,CK;Koblik,P;Breznock,B;Komtebedde,J;Pollycove,M;Hornof,WJ;Fisher,P
通讯作者：
Fisher,P

Comparison of shunt fraction estimation using transcolonic iodine-123-iodoamphetamine and technetium-99m-pertechnetate in a group of dogs with experimentally-induced chronic biliary cirrhosis.

使用跨结肠碘-123-碘苯丙胺和锝-99m-高锝酸盐对一组实验诱发的慢性胆汁性肝硬化的狗进行分流分数估计的比较。

DOI：
发表时间：
1991
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
0
作者：
Koblik,PD;Hornof,WJ;Yen,CK;Komtebedde,J;Breznock,E;Fisher,P
通讯作者：
Fisher,P

Use of technetium-99m sulfur colloid to evaluate changes in reticuloendothelial function in dogs with experimentally induced chronic biliary cirrhosis and portosystemic shunting.

使用 Technetium-99m 硫胶体评估实验性慢性胆汁性肝硬化和门体分流犬的网状内皮功能变化。