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Search for protein expression in amphetamines treated mouse heart : Challenge to the diagnosis for the sudden death of amphetamines abusers

Search for protein expression in amphetamines treated mouse heart : Challenge to the diagnosis for the sudden death of amphetamines abusers
寻找安非他明治疗小鼠心脏中的蛋白质表达：对安非他明滥用者猝死诊断的挑战
批准号：
22659138
负责人：
KUBO Shin-ichi
金额：
$1.94万
依托单位：
Fukuoka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659138/
关键词：
法医学覚醒剤心臓突然死心肥大致死性不整脈Methamphetamine2次元電気泳動MALDI-TOF-MSプラグラム細胞死mTOR経路カリウムチャネル遺伝子プログラム細胞死

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中文摘要
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英文摘要
In this study, the pathological changes of cardiac region, especially impulse conducting system in amphetamines(MA)-abusers was investigated. In long term MA-treated mouse-model, cardiac tissue was examined by 2-dementional electrophoresis to observe the changes of protein expressions. After long-term 0MA treatment, mTOR passway, related to program cell death(PCD) was activated. Gene expressions of potassium-channel associated genes were down regulated in MA-treated mouse. MA might change the action potential of cardiac cells to induce the cardiac sudden death.
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メタンフェタミン投与マウスの心臓におけるカリウムチャンネル関連遺伝子の発現
甲基苯丙胺处理小鼠心脏中钾通道相关基因的表达
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [松尾綾, 池松和哉, 中園一郎]
通讯作者： 中園一郎
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    25670347
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