IMPLANTABLE SELF-REGULATING OSMOTIC INSULIN PUMP

理想的植入型人工胰腺可以将胰岛素输送给 糖尿病患者对患者血糖水平的反应。 这将提供血糖的闭环控制，并将 模仿正常的、非糖尿病的胰腺的内分泌作用。 这样的设计可能会防止许多长期的并发症 糖尿病，如动脉粥样硬化、肾病和失明。我们 建议测试一种自我调节渗透胰岛素的可行性 泵，其胰岛素释放速率取决于血糖 集中精神。胰岛素输出的调节由一种 对水的渗透性是葡萄糖的新型膜- 依附的。合成这样一种膜是首要的 提案的重点。膜将由两层膜组成。 第一层将葡萄糖转化为葡萄糖酸，第二层将葡萄糖转化为葡萄糖酸 薄层是一种聚合物，在葡萄糖酸的存在下会膨胀， 增加了它的透水性。我们将确定聚合物 渗透率快速变化所必需的特性 考虑到pH值的变化，并最终导致葡萄糖浓度的变化。一次 优化了薄膜后，我们将把它包含在原型中 渗透泵。我们将在体外测试该泵以确定 自主调节渗透泵是否是一种可行的治疗方法 控制血糖。我们相信，这种方法将避免 与设备相关的某些设计问题，由 其他研究人员，依赖于其渗透性的膜 对胰岛素的反应受血糖水平的调节。

An ideal implantable artificial pancreas would deliver insulin to a diabetic patient in response to the patient's blood glucose level. This would provide closed-loop control of glycemia, and would mimic the endocrine action of the normal, nondiabetic pancreas. Such a devise might prevent many of the long term complications of diabetes, e.g. atherosclerosis, nephropathy and blindness. We propose to test the feasibility of a self-regulating osmotic insulin pump, whose rate of insulin release depends on blood glucose concentration. The regulation of insulin output is determined by a novel membrane whose permeability to water is glucose- dependent. The synthesis of such a membrane is the primary focus of the proposal. The membrane will consist of two lamina. The first lamina converts glucose to gluconic acid, and the second lamina is a polymer that swells in the presence of gluconic acid, increasing its water permeability. We will determine the polymer properties that are necessary for rapid changes in permeability given changes in pH, and ultimately glucose concentration. Once having optimized the membrane, we will include it in a prototype osmotic pump. We will test the pump in vitro to determine whether self-regulated osmotic pumping is a feasible means of controlling glycemia. We believe that this approach will obviate certain design problems associated with devices, proposed by other researchers, that depend on membranes whose permeability to insulin is modulated by blood glucose levels.