Novel MEMS and Microfluidic Platforms for Drug Delivery

描述(由申请人提供)：我们建议开发一套MEMS/微流控设备，这将对未来的药物输送系统有用。提出了三个项目：o在第一个项目中，将生产新型水凝胶/MEMS结构。这些结构将提供一种固体底物，允许药物释放速率受到各种信号分子的调节。我们将连接到MEMS基质水凝胶，其对大分子的渗透性可以被特定的抗原可逆地调节。我们还将开发新的MEMS/水凝胶配置，这将扩大这种组合的曲目。2.在第二个项目中，将使用快速微流控混合器来生产抗癫痫药物安定的过饱和溶液。这些溶液有望在足够长的时间内保持稳定，以便在鼻腔给药后迅速吸收。目前的工作将检验这样的假设，即微加工混合器产生的安定溶液将比处于相平衡的溶液更快地穿过膜。3.在第三个项目中，将建造一个简单的微流控装置，有望生产出极其均匀的水凝胶微球，并进行测试。

DESCRIPTION (provided by applicant): We propose to develop a suite of MEMS/microfluidic devices that will be useful for future drug delivery systems. Three projects are proposed: o In the first project, novel hydrogel/MEMS constructs will be produced. These constructs will provide a solid substrate that permits drug release rates to be modulated by a variety of signaling molecules. We will couple to MEMS substrates hydrogels whose permeability to macromolecules can be reversibly modulated by specific antigens. We will also develop new MEMS/hydrogel configurations which will expand the repertoire of this combination. 2. In the second project, a rapid microfluidic mixer will be used to produce supersaturated solutions of the antiepileptic drug, diazepam. These solutions are expected to remain stable long enough to be absorbed rapidly upon intranasal administration. The present work will test the hypothesis that the microfabicated mixer produces solutions of diazepam that will cross membranes much faster than solutions that are at phase equilibrium. 3. In the third project, a simple microfluidic device, which is expected to produce extremely uniform hydrogel microspheres, will be constructed and tested.