Novel MEMS and Microfluidic Platforms for Drug Delivery

用于药物输送的新型 MEMS 和微流体平台

• 批准号: 6738869
• 负责人: Ronald A Siegel
• 金额: $ 17.99万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6738869
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; diazepam; drug administration routes; drug delivery systems; fluid flow; gel; microcapsule; nonblood rheology; thermodynamics

DESCRIPTION (provided by applicant): We propose to develop a suite of MEMS/microfluidic devices that will be useful for future drug delivery systems. Three projects are proposed: o In the first project, novel hydrogel/MEMS constructs will be produced. These constructs will provide a solid substrate that permits drug release rates to be modulated by a variety of signaling molecules. We will couple to MEMS substrates hydrogels whose permeability to macromolecules can be reversibly modulated by specific antigens. We will also develop new MEMS/hydrogel configurations which will expand the repertoire of this combination. 2. In the second project, a rapid microfluidic mixer will be used to produce supersaturated solutions of the antiepileptic drug, diazepam. These solutions are expected to remain stable long enough to be absorbed rapidly upon intranasal administration. The present work will test the hypothesis that the microfabicated mixer produces solutions of diazepam that will cross membranes much faster than solutions that are at phase equilibrium. 3. In the third project, a simple microfluidic device, which is expected to produce extremely uniform hydrogel microspheres, will be constructed and tested.

描述（由申请人提供）：我们建议开发一套MEMS/微流体装置，这将是有用的未来药物输送系统。提出了三个项目：o在第一个项目中，将生产新型水凝胶/MEMS结构。这些构建体将提供固体基质，其允许药物释放速率被多种信号分子调节。我们将耦合到MEMS基板水凝胶，其渗透性的大分子可以通过特定的抗原可逆地调制。我们还将开发新的MEMS/水凝胶配置，这将扩大这种组合的剧目。2.在第二个项目中，将使用快速微流体混合器来生产抗癫痫药物地西泮的过饱和溶液。预期这些溶液保持稳定的时间足以在鼻内给药后迅速吸收。目前的工作将测试的假设，即微型混合器产生的解决方案，安定，将通过膜快得多的解决方案，在相平衡。3.在第三个项目中，将构建和测试一个简单的微流体装置，该装置有望产生极其均匀的水凝胶微球。