权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

LIFE STRESSORS IN DUODENAL ULCER--TWO SUBPOPULATIONS

十二指肠溃疡的生活压力源——两个亚群

基本信息

批准号：
3241697
负责人：
SUSAN B LEVENSTEIN
金额：
$ 2.53万
依托单位：
UNITA SANITARIA LOCALE, ROMA 1
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-09-01 至 1993-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3241697
关键词：
European adult human (21+) alcoholic beverage consumption anxiety behavioral medicine duodenal ulcer emotions endoscopy gastrointestinal disorder diagnosis human subject interview personality prognosis psychological stressor relapse /recurrence sign /symptom stress tobacco abuse

项目摘要

Methodological problems in pinpointing external stressors and the predominance of chronic disease in case series have impeded understanding of the relationship between life stress and duodenal ulcer. By appropriate choice of methods and patient population, this study aims to elucidate permissive and mediating factors in the psychosomatic process, and to define the natural history of stress-induced ulcer. It is hypothesized that life stress causes a distinct subgroup of ulcers, that this process is allowed by gastric hypersecretion and a certain personality structure and is mediated partially through anxiety-related abuse of alcohol, cigarettes, and coffee, and that ulcers arising from temporary stress may heal slowly but will have a good long-term prognosis. A pilot study has given support to several of these distinctive features of stress ulcers. The design calls for administration of a standardized interview instrument, validated in italy, to italian patients with endoscopically documented, recent-onset ulcer who do not have chronic symptoms and are not on maintenance therapy, in order to identify a subpopulation whose disease was preceded by distressing life experiences. The demographic and physiologic characteristics, use of ulcerogenic substances, mood and personality of this subgroup will then be compared with those of the rest of the ulcer population. Repeat endoscopy at six weeks will detect differences in short-term prognosis between the two groups, while periodic telephone interviews will permit comparison of their long-term course.

准确定位外部应激源的方法学问题和慢性病在系列病例中的主导地位阻碍了人们对生活压力与十二指肠溃疡的关系。按适当方式方法的选择和患者的人群，这项研究旨在阐明心身过程中的允许和中介因素，以及定义应激性溃疡的自然病史。这是假设的生活压力会导致一组不同的溃疡，这个过程是被胃部过度分泌和一定的人格结构所允许部分是通过与焦虑相关的酗酒、吸烟、和咖啡，暂时的压力引起的溃疡可能会慢慢愈合但会有很好的长期预后。一项初步研究已经给出了支持应激性溃疡的几个明显特征。设计呼吁管理经过验证的标准化面谈工具在意大利，对于内窥镜检查有记录的最近发病的意大利患者没有慢性症状和没有接受维持治疗的溃疡患者，为了识别疾病发生前的亚群痛苦的人生经历。人口统计学和生理学致溃疡物质的特点、用途、情绪和个性然后将这一亚组与溃疡的其他亚组进行比较人口。六周后重复内窥镜检查将检测到两组近期预后比较，同时定期电话治疗面谈将允许对他们的长期进程进行比较。