LIFE STRESSORS IN DUODENAL ULCER--TWO SUBPOPULATIONS

十二指肠溃疡的生活压力源——两个亚群

• 批准号: 3241694
• 负责人: SUSAN B LEVENSTEIN
• 金额: $ 4.87万
• 依托单位: UNITA SANITARIA LOCALE, ROMA 1
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3241694
• 关键词: European; adult human (21+); alcoholic beverage consumption; anxiety; behavioral medicine; duodenal ulcer; emotions; endoscopy; gastrointestinal disorder diagnosis; human subject; interview; personality; prognosis; psychological stressor; relapse /recurrence; sign /symptom; stress; tobacco abuse

Methodological problems in pinpointing external stressors and the predominance of chronic disease in case series have impeded understanding of the relationship between life stress and duodenal ulcer. By appropriate choice of methods and patient population, this study aims to elucidate permissive and mediating factors in the psychosomatic process, and to define the natural history of stress-induced ulcer. It is hypothesized that life stress causes a distinct subgroup of ulcers, that this process is allowed by gastric hypersecretion and a certain personality structure and is mediated partially through anxiety-related abuse of alcohol, cigarettes, and coffee, and that ulcers arising from temporary stress may heal slowly but will have a good long-term prognosis. A pilot study has given support to several of these distinctive features of stress ulcers. The design calls for administration of a standardized interview instrument, validated in italy, to italian patients with endoscopically documented, recent-onset ulcer who do not have chronic symptoms and are not on maintenance therapy, in order to identify a subpopulation whose disease was preceded by distressing life experiences. The demographic and physiologic characteristics, use of ulcerogenic substances, mood and personality of this subgroup will then be compared with those of the rest of the ulcer population. Repeat endoscopy at six weeks will detect differences in short-term prognosis between the two groups, while periodic telephone interviews will permit comparison of their long-term course.

确定外部压力源的方法问题和 病例系列中慢性疾病的优势阻碍了对 生活压力和十二指肠溃疡的关系 通过适当 方法的选择和患者人群，本研究旨在阐明 在心身过程中的许可和调解因素，并 定义应激性溃疡的自然史。 据推测 生活压力会导致一个独特的溃疡亚组，这个过程是 由于胃分泌过多和一定的性格结构允许， 部分是通过与焦虑相关的酗酒、吸烟 和咖啡，以及由暂时压力引起的溃疡可能会慢慢愈合 但长期预后良好 一项试点研究支持了 应激性溃疡的一些显著特征 设计 要求管理经验证的标准化访谈工具 在意大利，对于意大利患者， 没有慢性症状和没有接受维持治疗的溃疡， 为了确定一个亚群， 痛苦的人生经历 人口和生理 特征，致溃疡物质的使用，情绪和个性， 然后将该亚组与其余溃疡的亚组进行比较 人口 在六周内重复内窥镜检查将检测到 两组之间的短期预后，而定期电话 通过面谈可以比较他们的长期历程。