INFLUENCE OF HEREDITY ON MEAL PATTERNS IN HUMANS

遗传对人类膳食模式的影响

• 批准号: 3239893
• 负责人: John Manuel de Castro
• 金额: $ 10.51万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-15 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3239893
• 关键词: body weight; caloric dietary content; circadian rhythms; dietary carbohydrates; dietary constituent; dietary lipid; dietary proteins; eating; human population genetics; nutrition related tag; twin /multiplet

Recent evidence has strongly suggested that the adult body weight of humans is greatly influenced by heredity (Bouchard et. al., 1985; 1986; Bray; 1981; Stunkard et. al., 1986a; 1986b). Since body weight is principally produced and maintained by eating, the genes that influence body weight probably act by affecting food intake, specifically, the frequency, composition, or size of meals. There have been, however, no systematic studies of hereditary influences on the meal patterns of humans. The proposed research will investigate that aspect of eating behavior is genetically determined by studying and comparing the meal patterns of monozygotic (MZ) and dizygotic (DZ) twins. MZ and DZ twins will be asked to enter into a diary everything they either eat or drink and the time of the meals throughout a consecutive seven day period. The records will then be entered into a computer in coded form for analysis of the nutrient composition of the recorded meals. The similarities and differences between overall nutrient intakes and the microstructure of eating including the meal compositions, the intervals between meals, the meal pattern correlations, and the circadian distribution of eating will be determined separately for the MZ and DZ twins. The heritabilities of these factors will then be estimated based upon the difference between the intra-twin correlations for the MZ and DZ pairs. The proposed study should provide insights into how heredity influences the meal patterns of humans and in turn encodes and maintains body weight. This may suggest the nature of the physiological processes that are genetically influenced and suggest methods of intervention to prevent or treat abnormal body weight or eating behavior.

最近的证据强烈表明，成人体重 人类的遗传受到很大影响（Bouchard et.例如， 1985; 1986; Bray; 1981; Stunkard et.例如，1986 a; 1986 b）。 以来 体重主要是由饮食产生和维持的， 影响体重的基因可能通过影响食物来起作用 摄入量，特别是频率，组成，或膳食的大小。 然而，还没有系统的遗传研究。 对人类饮食模式的影响。 拟议研究 我将研究饮食行为的基因方面 通过研究和比较 单卵双胞胎（MZ）和双卵双胞胎（DZ）。 MZ和DZ双胞胎将 他们被要求把吃的喝的都记在日记里 以及连续七天的进餐时间 期 这些记录将被输入计算机， 营养成分分析表 吃饭。 整体营养素的异同 摄入量和饮食的微观结构， 食物组成、两餐之间的间隔、饮食模式 相关性，饮食的昼夜分布将是 MZ和DZ双胞胎分别测定。 的遗传力 这些因素将根据差异进行估计 同卵双胞胎和异卵双胞胎之间的相关性。 的 拟议的研究应该提供关于遗传如何影响 人类的饮食模式，反过来编码和维持身体 重量. 这可能暗示了生理过程的本质 受基因影响并提出干预方法的研究 以预防或治疗异常体重或饮食行为。