PHENOXY HERBICIDES AND SPONTANEOUS ABORTIONS IN ONTARIO

这项研究的主要目标是评估 接触苯氧类除草剂与患风湿性心脏病风险的关系 安大略省一群农场家庭的自然流产。虽然 有普遍的调查表明，这些 化学品对人类是致癌的，对胚胎有毒性和致畸作用。 动物，这项研究将是第一次在一个 农场人口，其中有大量育龄妇女 可能会暴露出来。农场运营的两个子队列，在 可能接触苯氧类除草剂的情况将根据 农业普查。农民夫妇将被邮寄调查问卷 它将获得有关使用的农用化学品的信息， 农场上的生育史活动和其他潜在风险 自然流产的因素。多元Logistic回归将是 用于评估苯氧类除草剂暴露对自发性的影响 流产，控制混杂因素。它们的广泛使用 农业和居住环境中的化学品(特别是 2，4-D)，从结果提示毒性的证据 流行病学和毒理学研究及其深远的后果 不利生殖的后果！对个体和 公众，建议这个话题值得进一步研究。

The primary objective of this study is to assess the relationship between exposure to phenoxy herbicides and the risk of spontaneous abortion in a cohort of Ontario farm families. Although there have been general investigations which have suggested that these chemicals are carcinogenic in humans and embryotoxic and teratogenic in animals, this study will be the first to examine this relationship in a farm population, in which a large number of reproductive-age women are potentially exposed. Two sub-cohorts of farm operations that vary in potential exposure to phenoxy herbicides will be identified based on the Census of Agriculture. Farming couples will be mailed questionnaires which will obtain information on agricultural chemicals used, reproductive history activities on the farm, and other potential risk factors for spontaneous abortion. Multiple logistic regression will be used to assess the effect of phenoxy herbicide exposure on spontaneous abortion, controlling for confounding factors. The wide usage of these chemicals, both in agricultural and residential settings (especially 2,4-D), the suggestive evidence of toxicity from the results of epidemiological and toxicological studies, and the profound consequences of adverse reproductive out!comes both to the individuals and the public, suggest that this topic warrants further study.