CORNEAL COLLAGENASE: CELLULAR AND BIOCHEMICAL CONTROL

角膜胶原酶：细胞和生化控制

• 批准号: 3256611
• 负责人: JEROME GROSS
• 金额: $ 14.77万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-01-01 至 1985-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3256611
• 关键词: cell cell interaction; cell growth regulation; collagenase; cornea disorder; corneal epithelium; corneal stroma; fluorescence microscopy; fluorescence spectrometry; histochemistry /cytochemistry; hormone regulation /control mechanism; mixed tissue /cell culture; nutrition related tag; radiotracer; scintillation counter; tissue /cell culture; vitamin A deficiency; zymogens

We will continue to concentrate on cell-cell interactions primarily between corneal epithelium and stromal cells, as a major regulatory mechanism for collagenolysis. Having identified stimulatory and inhibitory factors produced from low density and high density adult corneal epithelium under the influence of cytochalasin B, we will further purify and characterize these substances and also search for natural analogues in wounded corneal tissue which probably utilized the same cell surface receptors as does cytochalasin B. We are pursuing new lines of study opened this year on regulation of epithelial stromal cell interactions and tumor vascularization in the cornea by steroid hormones.

我们将继续专注于细胞间的相互作用，主要是 角膜上皮和基质细胞，作为一个主要的调节机制， 胶原溶解 在确定了刺激和抑制因子后， 从低密度和高密度成人角膜上皮的影响下， 细胞松弛素B，我们将进一步纯化和表征这些物质， 我还在受伤的角膜组织中寻找天然类似物， 利用与细胞松弛素B相同的细胞表面受体。 我们 今年开始的关于上皮基质调节的新研究 类固醇激素在角膜中的细胞相互作用和肿瘤血管形成。