PHENOXY HERBICIDES AND SPONTANEOUS ABORTIONS IN ONTARIO

安大略省的苯氧基除草剂和自然流产

• 批准号: 3253808
• 负责人: David A Savitz
• 金额: $ 18.67万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3253808
• 关键词: agriculture worker; data collection methodology /evaluation; environmental toxicology; epidemiology; female; health surveys; herbicides; human birth weight; interview; male; occupational hazard; pesticide biological effect; premature infant human; questionnaires; reproductive system disorder; spontaneous abortion; teratogens

The primary objective of this study is to assess the relationship between exposure to phenoxy herbicides and the risk of spontaneous abortion in a cohort of Ontario farm families. Although there have been general investigations which have suggested that these chemicals are carcinogenic in humans and embryotoxic and teratogenic in animals, this study will be the first to examine this relationship in a farm population, in which a large number of reproductive-age women are potentially exposed. Two sub-cohorts of farm operations that vary in potential exposure to phenoxy herbicides will be identified based on the Census of Agriculture. Farming couples will be mailed questionnaires which will obtain information on agricultural chemicals used, reproductive history activities on the farm, and other potential risk factors for spontaneous abortion. Multiple logistic regression will be used to assess the effect of phenoxy herbicide exposure on spontaneous abortion, controlling for confounding factors. The wide usage of these chemicals, both in agricultural and residential settings (especially 2,4-D), the suggestive evidence of toxicity from the results of epidemiological and toxicological studies, and the profound consequences of adverse reproductive out!comes both to the individuals and the public, suggest that this topic warrants further study.

本研究的主要目的是评估 接触苯氧基除草剂与患病风险之间的关系 安大略省农场家庭的自然流产。 虽然 一般性调查表明，这些 化学物质对人类具有致癌性，对胚胎具有毒性和致畸性 动物，这项研究将是第一个在动物中检验这种关系的研究 农业人口，其中大量育龄妇女 潜在暴露。 农场经营的两个子群体各不相同 将根据以下情况确定潜在的苯氧基除草剂暴露 农业普查。 农业夫妇将收到邮寄调查问卷 它将获得有关所用农用化学品的信息， 农场的繁殖史活动以及其他潜在风险 自然流产的因素。 多元逻辑回归将是 用于评估苯氧除草剂暴露对自发性的影响 流产，控制混杂因素。 这些的广泛使用 农业和住宅环境中的化学品（特别是 2,4-D)，从结果中得出的毒性提示证据 流行病学和毒理学研究及其深远的后果 对个人和群体的不良生殖后果 公众建议该主题值得进一步研究。