Nanoparticles to combat cellular dysfunction

纳米颗粒对抗细胞功能障碍

• 批准号: DP170102950
• 负责人: Dr Michael Whittaker
• 金额: $ 22.56万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170102950
• 关键词: Nanoparticles; combat; cellular; dysfunction

This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.

该项目旨在设计、合成和表征可以介导活性氧簇不利影响的纳米颗粒。该项目预计将开发具有定制化学功能的纳米颗粒，以调节活性氧的浓度，并开发一种平台技术，以解决活性氧过度产生的情况。该项目将研究纳米颗粒的物理化学性质如何影响其活性，以及它们如何影响生物环境中的细胞功能，组织形态和颗粒运输。该项目预计将有利于先进的制造业，兽医和医疗部门，并可能导致新的化疗药物。