Functional Materials to Hijack on Lipid Transport Pathways

劫持脂质运输途径的功能材料

• 批准号: DP220103654
• 负责人: Dr Michael Whittaker
• 金额: $ 31.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103654
• 关键词: Functional; Materials; Hijack; Lipid; Transport

This Project aims to provide new design rules for novel polymers with lipid elements that would allow them to interact with natural lipid trafficking pathways in precise ways. The anticipated goal is to generate a greater understanding on how these materials co-opt lipid transport pathways, serum albumins and lipoprotein nanoparticle assemblies, as a function of lipid component, molecular weight and macromolecular structure. Expected outcomes of this project may be novel lipid functional materials with tuneable pharmokinetics, plasma exposure, lymph exposure and biodistribution. These materials would have wide application in the pharmaceutical and veterinary industries.

该项目旨在为具有脂质元素的新型聚合物提供新的设计规则，使其能够以精确的方式与天然脂质运输途径相互作用。 预期的目标是更好地了解这些材料如何选择脂质转运途径，血清白蛋白和脂蛋白纳米颗粒组件，作为脂质组分，分子量和大分子结构的函数。 该项目的预期成果可能是具有可调药代动力学、血浆暴露、淋巴暴露和生物分布的新型脂质功能材料。这些材料将在制药和兽医工业中具有广泛的应用。