Functional Materials to Hijack on Lipid Transport Pathways

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This Project aims to provide new design rules for novel polymers with lipid elements that would allow them to interact with natural lipid trafficking pathways in precise ways. The anticipated goal is to generate a greater understanding on how these materials co-opt lipid transport pathways, serum albumins and lipoprotein nanoparticle assemblies, as a function of lipid component, molecular weight and macromolecular structure. Expected outcomes of this project may be novel lipid functional materials with tuneable pharmokinetics, plasma exposure, lymph exposure and biodistribution. These materials would have wide application in the pharmaceutical and veterinary industries.