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THE EFFECT OF OXIDATION UPON LENS TRANSPORT SYSTEMS

THE EFFECT OF OXIDATION UPON LENS TRANSPORT SYSTEMS
氧化对镜片传输系统的影响
批准号：
3259550
负责人：
ABRAHAM SPECTOR
金额：
$24.96万
依托单位：
COLUMBIA UNIV NEW YORK MORNINGSIDE
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
项目状态：
已结题
起止时间：
1983-12-01 至 1991-11-30
来源：
https://reporter.nih.gov/project-details/3259550
关键词：
NAD(H) phosphate adenosine diphosphate adenosine triphosphate aminoacid transport biological transport cataract drug screening /evaluation eye pharmacology glutathione hydrogen peroxide lactates lens membrane permeability nicotinamide adenine dinucleotide oxidation oxidation reduction reaction photochemistry potassium radioimmunoassay scintillation counter sodium

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中文摘要
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英文摘要
The aims of this project are to delineate the mechanism by which oxidation causes changes in lens transport systems. Three model systems will be used to examine transport. H2O2, hyperbaric O2 and photo-oxidation. Na/K ATPase, Ca ATPase and amino acid transport will be investigated. The impact of oxidative insult to the pump systems upon important metabolic parameters such as ATP, NAD(P) and NAD(P)H, lactate and glutathione will be examined. The model systems will be compared to human cataract to ascertain similarities in the pattern of cataract development. The origin of aqueous H2O2 and its relationship to ascorbate will also be investigated as well as initiation of a drug screening program to protect the lens membrane from oxidative insult.
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