SPATIAL COORDINATES OF VISUO VESTIBULO OCULAR REFLEXES

视觉前庭眼反射的空间坐标

• 批准号: 3259095
• 负责人: WERNER M GRAF
• 金额: $ 11.88万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-02-01 至 1989-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3259095
• 关键词: cerebellum; evolution; extraocular muscle; eye movements; fresh water environment; head movements; histology; neural information processing; neuroanatomy; neurophysiology; oculomotor nuclei; olivary body; optic tract; reflex; sensorimotor system; sequential perception; vestibular pathway; visual fields; visual perception

The overall goal of the proposed experiments is to describe the neuronal structure-function relationships of spatially and temporally coordinated eye and head movements by analyzing their intrinsic reference frame systems in both functional and phylogenetic contexts. The experimental paradigms include the spatial organization and central representation of the visual input to the olivo-cerebellar system, the functional anatomy of eye-head coordination, and the morphology and physiology underlying horizontal and vertical compensatory and voluntary eye movements. These objectives will be addressed in the following five specific aims. 1) The spatial organization of optokinetic input including its topographical and functional representation within the zones of the olivo-cerebellar system will be studied in cats and rabbits. 2) The descending projections of vertical and horizontal vestibular neurons to proximal neck movers will be determined in the cat. These specialized cervical projections are hypothesized to reflect the vestibular canal organization. 3) The structure-function relationship of vertical canal related second order vestibular neurons to compensatory and voluntary eye movements will be established in the cat. 4) The specialized horizontal eye movement pathways, consisting of the ascending tract of Deiters and abducens internuclear neurons will be investigated in a comparative approach utilizing rabbits, goldfish, and fish which are considered "living fossils". These experiments focus on the phylogenetic development of ocular frontalization and fovealization in vertebrates. 5) The reciprocal excitatory-inhibitory innervation of the vestibulo-oculomotor system will be ascertained in fish. This work emphasized phylogenetic continuity of the particular push-pull operational mode. Experimental techniques include acute and chronic animal preparations, three-dimensional visual and vestibular stimuli with extra-and intracellular recordings, extra- and intracellular horseradish peroxidase (HRP), 2-deoxyglucose, and eye movement recordings with a magnetic search coil system. The long term objectives of the proposal is to demonstrate that the central nervous system employs preferred coordinates in order to simplify calculation processes, when dealing with sensory-motor systems of high degrees of freedom. These preferred coordinates may be expressed in distinct intrinsic reference frame systems, that will be reflected by characteristic neuronal pathways.

拟议实验的总体目标是描述神经元 时空协调的结构-功能关系 通过分析眼睛和头部的内在参照系系统， 在功能和系统发育背景下。 实验范式 包括视觉的空间组织和中心表现， 橄榄-小脑系统的输入，眼-头的功能解剖 协调，和形态和生理基础的水平和 垂直补偿性和自主性眼球运动。 这些目标将 在以下五个具体目标中加以解决。 1)空间 视动输入的组织，包括其地形和 橄榄-小脑系统区域内的功能表征 将在猫和兔子身上进行研究。 2)的下降投影 垂直和水平前庭神经元近端颈部运动将是 这些专门的颈部投影是 假设反映前庭管组织。 3)的 垂直渠道二级结构-功能关系 前庭神经元的代偿性和自愿眼球运动将是 4）专门的水平眼球运动 通路，包括Deiters和外展肌的上行束 核间神经元将在比较的方法进行研究 利用兔子，金鱼和鱼，被认为是“活的”， 化石”。 这些实验的重点是 脊椎动物的眼额化和中央凹化。 5)倒数 前庭-眼神经系统的兴奋-抑制神经支配将 在鱼中发现。 这项工作强调了系统发育的连续性， 特定的推挽操作模式。 实验技术包括 急性和慢性动物制剂，三维视觉和 前庭刺激与细胞外和细胞内的记录，额外的和 细胞内辣根过氧化物酶（HRP）、2-脱氧葡萄糖和眼 用磁性搜索线圈系统记录运动。 长期 该提案的目的是证明中枢神经系统 系统采用优选坐标以简化计算 过程，当处理高度的感觉运动系统时， 自由 这些优选的坐标可以用不同的形式表示。 内在的参考框架系统，这将反映在特征 神经通路