EYE INFECTIONS BY TYPE 2 HERPES SIMPLEX VIRUS

新生儿疱疹性脉络膜视网膜炎的发病机制是 不太了解。 我们对新生兔子的初步研究显示 a）被2型单纯疱疹病毒感染的单核细胞 （HSV-2），而不是游离HSV-2，产生视网膜脉络膜炎; B）HSV-2 单核细胞上正常IgG的诱导Fc受体;和c） HSV-2感染的单核细胞需要正常IgG进行诱导 新生兔眼部病变的发生率。 根据这些观察， 以及其他研究人员的研究，以下致病过程 提出了新生儿视网膜脉络膜炎的发展： 感染时，HSV-2诱导单核细胞上正常IgG的Fc受体， 细胞 IgG与Fc受体的结合改变了抗体的性质。 细胞表面的HSV感染的单核细胞，并导致截留 视网膜和脉络膜毛细血管中的细胞。 截留的 然后HSV感染的单核细胞在该部位启动感染， 产生视网膜脉络膜炎。 为了检验这个提出的致病过程的有效性， 将进行一系列实验：a） 单核细胞是HSV-2的主要携带者， 确定在新生兔中产生视网膜脉络膜炎; B） 将研究HSV-2和单核细胞之间的相互作用， 将表征单核细胞上HSV诱导的Fc受体; c） IgG与HSV诱导的Fc受体的结合对细胞增殖的影响 单纯疱疹病毒感染单核细胞对视网膜脉络膜炎的诱导作用 将被评估。 最后，（d）HSV特异性抗体和 将测试HSVG感染的单核细胞上的抗病毒剂。 如果这一假设的有效性能够得到证实，我们的调查将 具有重要的医学意义：a） 新生儿疱疹性视网膜脉络膜炎将得到澄清，并有效 将找到预防和治疗疾病的方法; B） Fc受体在疱疹病毒感染发病机制中的生物学作用 将确定视网膜脉络膜炎;和c）这一发现 研究将有助于我们了解 由其他病毒引起的新生儿视网膜脉络膜炎，如 水痘-带状疱疹、巨细胞、麻疹和风疹病毒。

The pathogenic mechanism for herpetic chorioretinitis in the neonate is poorly understood. Our preliminary studies in the newborn rabbit revealed that a) mononuclear cells infected with type 2 herpes simplex virus (HSV-2), rather than free HSV-2, produce retinochoroiditis; b) HSV-2 induced Fc receptors for normal IgG on mononuclear cells; and c) mononuclear cells infected with HSV-2 required normal IgG for the induction of the ocular lesion in the newborn rabbits. Based on these observations, as well as those of other researchers, the following pathogenic process for the development of retinochoroiditis in the neonate is proposed: Following infection, HSV-2 induces Fc receptors for normal IgG on the mononuclear cells. The binding of IgG to the Fc receptors changes the nature of the cell surface of HSV-infected mononuclear cells and leads to the entrapment of the cell in the capillaries of the retina and choroid. The entrapped HSV-infected mononuclear cell then initiates infection at the site and produces retinochoroiditis. To examine the validity of this proposed pathogenic process, the following series of experiments will be carried out: a) subpopulations of mononuclear cells which are major carriers of HSV-2 and are capable of producing retinochoroiditis in the newborn rabbits will be determined; b) the interaction between HSV-2 and mononuclear cells will be studied, and HSV-induced Fc receptors on the mononuclear cells will be characterized; c) the effects of binding of IgG to HSV-induced Fc receptors on the HSV-infected mononuclear cells and on the induction of retinochoroiditis will be evaluated. Finally, (d) the effect of HSV-specific antibody and of the antiviral agents on the HSVG-infected mononuclear cells will be tested. If the validity of this hypothesis can be proven, our investigation will have important medical implications: a) The pathogenic process for neonatal herpetic retinochoroiditis will be clarified, and an effective means of preventing and treating the disease will be found; b) the biological role of Fc receptors in the pathogenesis of herpetic retinochoroiditis will be identified; and c) the findings of this investigation will shed some light in our understanding of pathogenesis of retinochoroiditis in the newborn produced by other viruses, such as varicella-zoster, cytomegalo, measles and rubella viruses.