EYE INFECTION OF CYTOMEGALOVIRUS
EYE INFECTION OF CYTOMEGALOVIRUS
批准号:
3265144
负责人:
JANG O OH
金额:
$18.42万
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-05-01 至 1994-04-30
中文摘要
人类巨细胞病毒(CMV)引起的许多眼部疾病是常见的
英文摘要
Many ocular diseases of cytomegalovirus (CMV) in humans are
opportunistic infections of the eye and occur predominantly in
immunosuppressed individuals. As the number of immunosuppressed
patients increases in recent years due largely to acquired
immunodeficiency syndrome (AIDS), CMV has become the causal agent
for an important eye disease. Yet, the pathogenesis of CMV eye
infection is poorly understood at present. In view of ten serious
nature of CMV eye infection and even increasing incidence of CMV
eye infection among AIDS patients, a critical assessment of the
role of CMV in human eye infection as well as a comprehensive study
of the nature of the disease are urgently needed.
Our preliminary studies on murine CMV (MCMV) eye infection clearly
showed that as in humans, the intact host cellular immunity is an
important factor for the protection of the mouse from the infection
and recurrence of MCMV. Therefore, as our initial efforts to
evaluate the effect of host cellular immunity on the pathogenesis
of CMV eye infection, the following series of experiments is
proposed:
1) Roles of various cellular immune components of the mouse, namely
helper T cells (L3T4+ cells), suppressor T cells (Lyt-2+ cells),
natural killer cells and macrophages in the induction of viremia
and primary eye infection during systemic infection of MCMV will
be studied.
2) The establishment of latency of MCMV in the eye and macrophages
following primary infection will be examined, and the location of
the virus genomes in the eye tissues will be determined by means
of co-culture method and DNA-DNA hybridization techniques with
MCMV-DNA probes.
3) Cellular immune components which may be responsible for in vivo
reactivation of latent MCMV in the eye will be identified by
evaluating the effect of selective depletion of each immune
component on the reactivation of the latent virus.
The proposed study will provide us hitherto unavailable information
on CMV eye infection which will shed some light on our
understanding of pathogenesis of the disease and also will assist
us in the search for effective means for the prevention and
treatment of CMV infections in humans.
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EYE INFECTION OF CYTOMEGALOVIRUS
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批准号:2161821
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项目类别:
-
资助金额:$24.04万
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财政年份:1989
-
负责人:JANG O OH
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依托单位:
EYE INFECTION OF CYTOMEGALOVIRUS
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批准号:3265147
-
项目类别:
-
资助金额:$22.93万
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财政年份:1989
-
负责人:JANG O OH
-
依托单位:
EYE INFECTION OF CYTOMEGALOVIRUS
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批准号:3265146
-
项目类别:
-
资助金额:$21.65万
-
财政年份:1989
-
负责人:JANG O OH
-
依托单位:
EYE INFECTION OF CYTOMEGALOVIRUS
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批准号:3265145
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项目类别:
-
资助金额:$19.92万
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财政年份:1989
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负责人:JANG O OH
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依托单位:
RECURRENT HERPES SIMPLEX UVEITIS
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批准号:3255635
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项目类别:
-
资助金额:$2.45万
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财政年份:1980
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负责人:JANG O OH
-
依托单位:
EYE INFECTIONS BY TYPE 2 HERPES SIMPLEX VIRUS
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批准号:3256030
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项目类别:
-
资助金额:$15.29万
-
财政年份:1976
-
负责人:JANG O OH
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依托单位:
EYE INFECTIONS BY TYPE 2 HERPES SIMPLEX VIRUS
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批准号:3256029
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项目类别:
-
资助金额:$15.09万
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财政年份:1976
-
负责人:JANG O OH
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依托单位:
EYE INFECTIONS BY TYPE 2 HERPES SIMPLEX VIRUS
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批准号:3256031
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项目类别:
-
资助金额:$16.26万
-
财政年份:1976
-
负责人:JANG O OH
-
依托单位:
EYE INFECTIONS BY TYPE 2 HERPES SIMPLEX VIRUS
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批准号:3256033
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项目类别:
-
资助金额:$16.99万
-
财政年份:1976
-
负责人:JANG O OH
-
依托单位:
EYE INFECTIONS BY TYPE 2 HERPES SIMPLEX VIRUS
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批准号:3256032
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项目类别:
-
资助金额:$16.12万
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财政年份:1976
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负责人:JANG O OH
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依托单位:
海外基金