MICROCIRCUITRY OF PARALLEL CHANNELS IN PRIMATE VISION

人类的视觉表现取决于平行功能 通道建立在视觉处理的早期阶段。 每个心理物理定义的通道可能依赖于贡献 来自几种类型的神经节细胞。反过来，贡献 每种类型的神经节细胞的来源取决于其结构 阵列及其布线到特定类型的光感受器。我们的 广泛的目标是确定视网膜显微解剖 在这些心理物理和生理基础上 目标是：1)在灵长类动物的中心凹区域进行识别 (猕猴)视网膜，与人类非常相似，所有的 存在的神经节细胞的类型。2)确定 每种类型的数组结构。3)确定详细的 每种类型的连接件均带有杆件和彩色标识 圆锥体。4)将这些信息合并到计算模型中 模拟神经节细胞在不同环境下的表现 亮度和光谱组成的条件。这些发现 将为将解剖电路连接到 生理学和心理物理学。我们的战略是研究 中心凹中心有一小块密集的视网膜， 在空间敏锐度高的地方，也有杆状突起，并且 神经节细胞堆积成多列。我们会 将组织分成两组超薄切片，一组 径向的和另一个切向的，在电子中拍摄它们 显微镜，并创建每个完整的摄影蒙太奇。 我们将使用径向级数来识别类型及其 电路和切级数研究的结构 各种阵列。

Human visual performance depends on parallel functional channels established in the early stages of visual processing. Each psychophysically defined channel may depend on contributions from several types of ganglion cell. In turn, the contribution from each type of ganglion cell depends on the structure of its array and its wiring to specific types of photoreceptor. Our broad goal is to determine the retinal microanatomy that underlies these psychophysical and physiological aims are: 1) Identify in the foveal region of the primate (macaque) retina, which closely resembles the human, all the types of on ganglion cell that are present. 2) Determine the array structure of each type. 3) Determine the detailed connections of each type with rods and chromatically identified cones. 4) Incorporate this information into computational models that simulate ganglion cell performance under different conditions of luminance and spectral composition. These findings will provide a basis for linking the anatomical circuitry to the physiology and psychophysics. Our strategy is to study intensively a small patch of retina just off the foveal center, where spatial acuity is high, yet rods are also present, and where ganglion cells are stacked in multiple ranks. We will prepare the tissue in two series of ultrathin sections, one radial and the other tangential, photograph them in the electron microscope, and create complete photographic montages of each. We shall use the radial series to identify types and their circuitry and the tangential series to study the structure of the various arrays.