MICROCIRCUITRY OF PARALLEL CHANNELS IN PRIMATE VISION

灵长类动物视觉中并行通道的微电路

• 批准号: 3265298
• 负责人: PETER STERLING
• 金额: $ 22.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265298
• 关键词: Macaca; amacrine cells; computer simulation; cone cell; electron microscopy; light adaptations; neuroanatomy; neurophysiology; psychophysics; retina; retinal adaptation; retinal bipolar neuron; retinal ganglion; rod cell; synapses; vision; visual photoreceptor

Human visual performance depends on parallel functional channels established in the early stages of visual processing. Each psychophysically defined channel may depend on contributions from several types of ganglion cell. In turn, the contribution from each type of ganglion cell depends on the structure of its array and its wiring to specific types of photoreceptor. Our broad goal is to determine the retinal microanatomy that underlies these psychophysical and physiological aims are: 1) Identify in the foveal region of the primate (macaque) retina, which closely resembles the human, all the types of on ganglion cell that are present. 2) Determine the array structure of each type. 3) Determine the detailed connections of each type with rods and chromatically identified cones. 4) Incorporate this information into computational models that simulate ganglion cell performance under different conditions of luminance and spectral composition. These findings will provide a basis for linking the anatomical circuitry to the physiology and psychophysics. Our strategy is to study intensively a small patch of retina just off the foveal center, where spatial acuity is high, yet rods are also present, and where ganglion cells are stacked in multiple ranks. We will prepare the tissue in two series of ultrathin sections, one radial and the other tangential, photograph them in the electron microscope, and create complete photographic montages of each. We shall use the radial series to identify types and their circuitry and the tangential series to study the structure of the various arrays.

人类的视觉表现取决于并行功能 在视觉处理的早期阶段建立的通道。 每一个精神病理学定义的通道可能取决于贡献 来自几种神经节细胞。 反过来，贡献 每种类型的神经节细胞取决于其结构， 阵列及其布线到特定类型的感光器。 我们 一个广泛的目标是确定视网膜的显微解剖结构， 是这些心理和生理问题的基础 目的是：1）在灵长类动物的中央凹区域识别 （猕猴）视网膜，非常类似于人类，所有的 存在的神经节细胞的类型。 2)确定 每种类型的数组结构。 3)确定详细的 每种类型的连接杆和彩色标识 圆锥体。 4)将此信息纳入计算模型 模拟神经节细胞在不同环境下的表现 亮度和光谱组成的条件。 这些发现 将为将解剖电路连接到 生理学和心理物理学。 我们的策略是研究 集中在离中央凹中心不远的一小片视网膜上， 其中空间敏锐度高，但也存在杆，并且 其中神经节细胞以多个等级堆叠。 我们将 将组织制备成两个系列的切片，一个 另一个是切向的，用电子照相 显微镜，并创建每个完整的摄影蒙太奇。 我们将使用径向系列来识别类型及其 电路和切向级数来研究 各种数组。