AQUEOUS HUMOR DYNAMICS AND VANADATE

水相动力学和钒酸盐

• 批准号: 3258053
• 负责人: STEVEN D PODOS
• 金额: $ 17.56万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-07-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3258053
• 关键词: adenosinetriphosphatase; adenylate cyclase; ascorbate; cyclic GMP; dosage; eye agent; eye disorder diagnosis; fluorimetry; glaucoma; intraocular fluid; intraocular pressure; radioimmunoassay

Vanadate, a sodium-potassium ATPase inhibitor and adenylate cyclase stimulator, was found to lower intraocular pressure when topically applied to the eyes of rabbits and monkeys. As this class of compound may be useful in the treatment of glaucoma, the present proposal will study vanadate's efficacy, toxicity and mode of action in the eyes of monkeys. Single and multiple dose-response studies will be carried out measuring intraocular pressure, tonographic outflow facility, aqueous flow by fluorophotometry and episcleral venous pressure in the anesthetized monkey. The effect of vanadate on aqueous and/or ciliary body levels of cyclic AMP, adenylate cyclase and (Na plus K)-ATPase will be measured and correlated with its effect on aqueous humor dynamics. The intraocular pressure effect of vanadate treatment of monkey eyes made glaucomatous by laser burning of the outflow pathways will be examined.

钒酸盐，一种钠钾atp酶抑制剂和腺苷酸环化酶刺激剂，

项目成果

Transepithelial electrical measurements on the isolated rabbit iris-ciliary body.

对离体兔虹膜睫状体进行跨上皮电测量。

• DOI: 10.1016/0014-4835(84)90096-4
• 发表时间: 1984
• 期刊: Experimental eye research
• 影响因子: 3.4
• 作者: Krupin,T;Reinach,PS;Candia,OA;Podos,SM
• 通讯作者: Podos,SM