PATHOPHYSIOLOGIC MECHANISMS IN OCULAR HYPOTONY

眼肌张力减退的病理生理机制

• 批准号: 3257585
• 负责人: JONATHAN E. PEDERSON
• 金额: $ 13.68万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3257585
• 关键词: combination chemotherapy; eye agent; eye disorder; eye disorder diagnosis; eye pharmacology; fluorimetry; glaucoma surgery; human subject; human therapy evaluation; intraocular fluid; intraocular pressure; methacholine; physostigmine; radiotracer; retina detachment; retina disorder

Clinical and animal studies of eyes with hypotony will be performed to evaluate the mechanisms of hypotony. Experimental models of ciliochoroidal detachment, retinal detachment, and cyclodialysis in monkeys have been developed which result in hypotony. Aqueous flow studies and vitreous flow studies will be performed in these models by use of radioisotope tracers and fluorophotometry. In addition, aqueous flow by flurophotometry will be measured in cases of hypotony. A drug combination of methacholine plus eserine has been shown to reverse experimental hypotony by reducing uvecscleral aqueous outflow. Additional drugs will be investigated for potential use in the treatment of ocular hypotony.

将对低眼压眼进行临床和动物研究，以评价 低眼压的机制 睫状体脉络膜脱离的实验模型， 视网膜脱离和睫状体脱离， 导致低眼压。 将进行房水流动研究和玻璃体流动研究。 通过使用放射性同位素示踪剂和荧光光度法在这些模型中进行。 此外，在以下情况下，将通过荧光光度法测量房水流量： 低眼压 乙酰甲胆碱加艾司氯胺酮的药物组合已被证明， 通过减少色素层巩膜房水流出来逆转实验性张力减退。 将研究其他药物是否可能用于治疗 眼压过低