INPUT-OUTPUT ORGANIZATION OF THE SUPERIOR COLLICULUS

拟议研究的目标是详细检查投入产出 上丘层以下各层的组织 为方位反应提供感觉运动机制的视盘。我们 将决定彼此之间的关系和顶盖传出 几个主要的丘状传入连接的神经元，其中大多数 以不连续的“柱状”模式终止。我们的努力将是 尤其集中在从额叶和丘脑的输入 顶叶大脑皮层、黑质、三叉神经复合体、 小脑和视网膜。这些研究是解剖学的，使用了几个 当代轴浆运输技术单独和结合在 光镜水平的分析。这些项目的完成将 更清楚地了解上丘是如何执行的 它在定向行为中的重要作用，也是有意义的 生理和行为调查，更普遍地说， 对中枢神经的模块化组织有了新的见解 高等哺乳动物的系统。

The goal of the proposed research is to examine in detail the input-output organization of the layers of the superior colliculus below the stratum opticum that provide sensorimotor mechanisms for orientation responses. We will determine the relationships to one another and to tectal efferent neurons of several major collicular afferent conections, most of which terminate in a discontinuous "columnar" pattern. Our efforts will be concentrated especially on inputs to the colliculus from the frontal and parietal cerebral cortex, the substantia nigra, the trigeminal complex, the cerebellum, and the retina. The studies are anatomical using several contemporary axoplasmic transport technics alone and in combination at the light microscopic level of analysis. Completion of these projects will provide a clearer understanding of how the superior colliculus carries out its important role in orientation behavior, and a groundwork for meaningful physiological and behavioral investigations and should, more generally, yield new insight into the modular organization of the central nervous system of higher mammals.