INPUT-OUTPUT ORGANIZATION OF THE SUPERIOR COLLICULUS

上丘的输入输出组织

• 批准号: 3263345
• 负责人: ROBERT M BECKSTEAD
• 金额: $ 7.33万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1987-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3263345
• 关键词: autoradiography; axon; cerebellum; cerebral cortex; histochemistry /cytochemistry; microscopy; neuroanatomy; neuronal transport; neurophysiology; orientation; parietal lobe /cortex; prosencephalon; radionuclide double label; retina; sensorimotor system; spinal trigeminal nucleus; substantia nigra; superior colliculus; visceral afferent nerve

The goal of the proposed research is to examine in detail the input-output organization of the layers of the superior colliculus below the stratum opticum that provide sensorimotor mechanisms for orientation responses. We will determine the relationships to one another and to tectal efferent neurons of several major collicular afferent conections, most of which terminate in a discontinuous "columnar" pattern. Our efforts will be concentrated especially on inputs to the colliculus from the frontal and parietal cerebral cortex, the substantia nigra, the trigeminal complex, the cerebellum, and the retina. The studies are anatomical using several contemporary axoplasmic transport technics alone and in combination at the light microscopic level of analysis. Completion of these projects will provide a clearer understanding of how the superior colliculus carries out its important role in orientation behavior, and a groundwork for meaningful physiological and behavioral investigations and should, more generally, yield new insight into the modular organization of the central nervous system of higher mammals.

拟议研究的目标是详细审查投入产出 层下上级丘层的组织 提供定向反应的感觉运动机制的视神经。 我们 将决定彼此之间以及与顶盖传出神经之间的关系 神经元的几个主要丘传入连接，其中大多数 以不连续“柱状”图案终止。 我们的努力将是 特别是集中在从额叶到丘的输入， 顶叶大脑皮层，黑质，三叉神经复合体， 小脑和视网膜。 这些研究是解剖学的， 当代轴浆运输技术单独和组合在 光学显微镜水平的分析。 这些项目的完成将 更清楚地了解上级丘如何执行 它在定向行为中的重要作用，以及有意义的 生理和行为研究，更一般地说， 对中枢神经系统的模块化组织有了新的认识 高等哺乳动物系统。