DEVELOPMENT OF HYPERACUITY

这个项目的目标集中在对 猕猴的空间视觉发育。这些猴子形成了 一种动物模型，可以用来检验关于 发育过程及其破坏的神经基础 斜视性弱视。我们将研究发展 正常幼猴和幼猴空间视觉的几个方面 在实验中诱发斜视的猴子 评价视力超敏的神经基础和神经基础的理论 斜视性弱视的基本空间缺陷。首先，我们将 解决了正常的新生儿中心凹加工和 斜视视觉处理类似于正常的外周视觉处理， 并调查了基于现场的空间赤字的性质 实验中的性嗜性猴子。第二，我们将尝试 确定视觉信息的“抽样”的性质 正常的幼猴和调查正常的 外周和斜视视觉系统在空间上 采样不足。第三，我们将进行生理学和 对我们的影响的神经基础的解剖学研究 进行了心理生理检查。 这些实验涉及两种标准的行为方法 测试：优先外观和可操作的调节。全 心理物理数据将通过这些方法中的一种获得。 生理学研究，将进行，以评估 心理物理定义的功能的神经基础，将 使用标准电生理记录来完成 技巧。猕猴被用于这些研究，以便 可以在严格控制下获得纵向数据 条件，这样潜在的神经功能就可以 在视觉功能良好的动物身上进行研究， 被证明与人类相似。

The goals of this project center on the characterization of spatial vision development in macaque monkeys. These monkeys form an animal model that can be used for testing hypotheses about the neural basis for the developmental processes and their disruption in strabismic amblyopia. We will be studying the development of several aspects of spatial vision in normal infant monkeys and in monkeys who have experimentally-induced strabismus in order to evaluate theories of the neural basis of hyperacuity and of the basic spatial deficit in strabismic amblyopia. First, we will address the idea that both normal neonatal foveal processing and strabismic visual processing resemble that in the normal periphery, and investigate the field-based nature of the spatial deficit in experimentally esotropic monkeys. Second, we will attempt to determine the nature of the "sampling" of visual information in normal infant monkeys and investigate the notion that the normal periphery and the strabismic visual system are spatially undersampled. Third, we will undertake physiological and anatomical studies of the neural basis of the effects we have examined psychophysically. The experiments involve two standard methods for behavioral testing: preferential looking and operant conditioning. All psychophysical data will be obtained by one of these methods. Physiological studies, which will be conducted in order to evaluate the neural bases of the psychophysically defined functions, will be accomplished using standard electrophysiological recording techniques. Macaque monkeys are used for these studies so that longitudinal data can be obtained under carefully controlled conditions, and so that the underlying neural function can be studied in animals whose visual function is well-characterized and demonstrated to be similar to that of humans.