CHARACTERIZATION OF THE MAMMALIAN REOVIRUS RECEPTOR

哺乳动物呼肠孤病毒受体的特征

• 批准号: 3265385
• 负责人: MARK I GREENE
• 金额: $ 25.91万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-02-01 至 1994-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265385
• 关键词: Reoviridae disease; antiidiotype antibody; beta adrenergic receptor; binding proteins; cell differentiation; central nervous system neoplasms; genetic library; heart; isoelectric point; lung; molecular cloning; neuroblastoma; neurons; nucleic acid inhibitor; nucleic acid probes; nucleic acid sequence; phosphorylation; protein structure; proteolysis; radioimmunoassay; radiotracer; virus cytopathogenic effect; virus protein

The objectives of this proposal are to study the cellular proteins which mediate cell attachment of the mammalian reovirus type 3. Through the study of the viral binding protein (receptor), we hope to better understand the processes of viral infectivity and pathogenesis and the potential roles and effects of receptor modulation on these processes. We will characterize the similarities of the reovirus to the mammalian beta-adrenergic receptor.

该提案的目的是研究细胞蛋白质， 介导哺乳动物呼肠孤病毒3型的细胞附着。 通过 研究病毒结合蛋白（受体），希望能更好地了解 病毒感染和致病的过程及其潜在的作用 以及受体调节对这些过程的影响。 我们将描述呼肠孤病毒与哺乳动物病毒的相似性， β-肾上腺素能受体