QUANTIFYING THE TONIC FORCE EFFECT OF STRABISMUS

我们建议评估手术的效果(经济衰退， 切除)和局部注射药物(肉毒杆菌毒素， 丁哌卡因)对琥珀胆碱刺激的眼外肌的影响 张力(SSMT单位为克)。之前没有人尝试过 为了量化斜视治疗方案对患者视力的影响 主音子系统，有选择地。为此，我们描述了一种 用于量化响应中产生的SSMT的方法 到按重量剂量的琥珀酰胆碱作为连续给药 静脉滴注。 我们试图应用这种方法来定义 SSMT，在拮抗者内部和之间同时产生 眼外肌对(内侧与外侧)，1)国内 猫(非斜视对照)；2)固定剂量前后 后退或切除；3)注射前后 肉毒杆菌毒素或布比卡因；以及，4)比较 药物与手术在SSMT中的数量和比例，拮抗剂 肌肉组合。 我们相信，这些数据将导致一个客观的方法来 量化并比较这些模式对紧张度的影响 系统，并因此为研究提供了一个模型 药理作用药物的研究进展 在数量上与非手术方法的手术效果相似。

We propose to evaluate the effects of surgery (recession, resection) and local injection of drugs (botulinum toxin, bupivicaine) on the succinylcholine-stimulated extraocular muscle tension (SSMT in grams). There have been no previous attempts to quantify the effects of strabismus therapeutic options on the tonic subsystem, selectively. To this end, we have described a method for the quantification of the SSMT generated in response to a by-weight dose of succinylcholine delivered as a continuous intravenous drip. We seek to apply this method to define the amounts and ratios of SSMT, simultaneously generated within and among antagonist pairs of extraocular muscles (medial vs. lateral), 1) in domestic cats (non-strabismic controls); 2) before and after a fixed amount of recession or resection; 3) before and after the injection of botulinum toxin or bupivicaine; and, 4) to compare the effects of drugs vs. surgery on the SSMT, amounts and ratios, in antagonist muscle pairs. We believe that these data will result in an objective method to quantify and compare the impact of these modalities on the tonic system, and as such, provide a model for the research and development of pharmacologic agents for the attainment of quantitatively similar surgical effects with nonsurgical methods.