Exploiting bacteriocins for plant protection against bacterial infections
利用细菌素保护植物免受细菌感染
基本信息
- 批准号:BB/T004207/1
- 负责人:
- 金额:$ 25.75万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2019
- 资助国家:英国
- 起止时间:2019 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Pseudomonas syringae is a bacterial species that causes disease in over 28 important crops and field losses & spoilage in storage run into $billions worldwide. For annual crops, the primary route of infection is via contaminated seed. The market for seed treatment exceeds $58bn annually but using chemicals or conventional antibiotics is increasingly regarded as having negative environmental consequences. Nearly all bacteria, including Pseudomonas spp., produce bacteriocins, protein antibiotics that kill related species. We have identified bacteriocins from Pseudomonas spp., have produced them in pure form and shown that they effectively kill field isolates of P. syringae isolated from infected crops. When applied to seed they substantially reduce growth of P. syringae. We propose to develop the use of bacteriocins as a seed treatment by optimizing treatment and seed coating conditions and identifying novel bacteriocin species for use in bacteriocin cocktails.
假单胞菌是一种细菌物种,在超过28种重要作物中引起疾病,在全球范围内,田间损失和储存中的腐败达到数十亿美元。对于一年生作物,感染的主要途径是通过受污染的种子。种子处理市场每年超过580亿美元,但使用化学品或传统抗生素越来越被认为会对环境产生负面影响。几乎所有的细菌,包括假单胞菌,产生细菌素,杀死相关物种的蛋白质抗生素。我们已经鉴定了来自假单胞菌属的细菌素,已经生产出纯的形式,并显示它们有效地杀死从受感染的作物中分离出的P.eriningae的田间分离物。当施用于种子时,它们显著降低了P.dichloroacetate的生长。我们建议通过优化处理和种子包衣条件以及鉴定用于细菌素混合物的新型细菌素种类来开发细菌素作为种子处理的用途。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Challenges of using protein antibiotics for pathogen control.
使用蛋白质抗生素控制病原体的挑战。
- DOI:10.1002/ps.6312
- 发表时间:2021
- 期刊:
- 影响因子:4.1
- 作者:Chai R
- 通讯作者:Chai R
Bacteriocins Targeting Gram-Negative Phytopathogenic Bacteria: Plantibiotics of the Future.
- DOI:10.3389/fmicb.2020.575981
- 发表时间:2020
- 期刊:
- 影响因子:5.2
- 作者:Rooney WM;Chai R;Milner JJ;Walker D
- 通讯作者:Walker D
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Joel Milner其他文献
Balancing the scales: assessing the impact of irrigation and pathogen burden on potato blackleg disease and soil microbial communities
- DOI:
10.1186/s40168-024-01918-6 - 发表时间:
2024-10-21 - 期刊:
- 影响因子:12.700
- 作者:
Ciara Keating;Elizabeth Kilbride;Mark A. Stalham;Charlotte Nellist;Joel Milner;Sonia Humphris;Ian Toth;Barbara K. Mable;Umer Zeeshan Ijaz - 通讯作者:
Umer Zeeshan Ijaz
Joel Milner的其他文献
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{{ truncateString('Joel Milner', 18)}}的其他基金
A Decision Support tool for Potato Blackleg Disease (DeS-BL)
马铃薯黑胫病决策支持工具 (DeS-BL)
- 批准号:
BB/T010649/1 - 财政年份:2020
- 资助金额:
$ 25.75万 - 项目类别:
Research Grant
Defence and defence suppression in plant pathogen interactions: the role of CaMV protein P6
植物病原体相互作用中的防御和防御抑制:CaMV 蛋白 P6 的作用
- 批准号:
BB/D017319/1 - 财政年份:2006
- 资助金额:
$ 25.75万 - 项目类别:
Research Grant
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