PERIPHERAL TESTS OF COLOR VISION IN THE EARLY DIAGNOSIS

早期诊断中色觉的外围测试

• 批准号: 3262945
• 负责人: WILLIAM M HART
• 金额: $ 15.26万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3262945
• 关键词: color blindness; color visions; early diagnosis; glaucoma; glaucoma test; human subject; noninvasive diagnosis; perimetry; visual fields

Our objective to develop non-invasive visual function tests to improve the detection and diagnosis of glaucoma at the earliest stages of the disease. The visual function tests being evaluated are measures of color perception outside of the usual areas for such tests. Rather than studying color vision at the center of the visual field, we are looking at color contrast and spectral sensitivity functions in more peripheral locations in the visual field. Color contrast perimetry involves the use of variably colored test lights produced by a microcomputer controlled color video device, while peripheral spectral sensitivity tests measure the sensitivity for detection of variably colored test lights in the presence of strongly color adapting surrounds. Prior study of color vision defects in patients with glaucoma have suggested that damage to the perception of blue/yellow color contrast may occur prior to the onset of glaucomatous damage detectable by conventional (perimetric) forms of testing. The specific aims of this proposal are: (1) To prospectively evaluate the sensitivity of extrafoveal tests of color vision for the detection of earliest glaucomatous visual field defects in a population of patients known to be at high risk; (2) To test the hypothesis that glaucomatous visual field defects detected by extrafoveal tests of color vision antedate the appearance of defects as mapped by conventional threshold static perimetry. Efforts to improve the sensitivity and specificity of techniques used to diagnose the earliest stages of glaucoma are being sought so as to improve the chances of preventing irreversible loss of vision in patients who ultimately develop the disease. There is a need for improved techniques of early diagnosis since current methods allow detection of the disease only at a relatively advance stage. Once the disease is established, and in spite of the best available medical and surgical therapy, there remains a disturbingly high incidence of inexorable loss of vision. It is hoped that by improving the sensitivity of early diagnosis of the disease, that appropriate therapy can be instituted for affected individuals at an earlier stage, increasing the likelihood of preservation of vision over the subsequent course of the disease.

我们的目标是开发非侵入性的视觉功能测试， 提高青光眼的早期检测和诊断 疾病的阶段。 视觉功能测试 评估的是通常的颜色感知以外的措施， 进行此类测试的区域。 而不是在研究色觉 在视野中心，我们看到的是颜色对比 而光谱灵敏度函数在更外围的位置 在视觉领域。 彩色对比视野检查包括使用 由微型计算机产生的彩色测试光 控制彩色视频设备，而外围光谱 灵敏度测试测量检测以下物质的灵敏度： 在存在强烈颜色的情况下， 适应环境。 色觉缺陷的先前研究 青光眼患者认为， 蓝/黄颜色对比的感知可能发生在 通过常规检查可检测到的昏迷性损伤的发生 （周长）测试形式。 具体目标是 建议如下： (1)前瞻性评价中心凹外 色觉测试，用于检测最早的 青光眼患者的视野缺损 已知处于高风险; (2)为了验证昏迷的视野 色觉中心凹外检测缺陷 通过常规阈值映射的缺陷的出现 静态视野检查 努力提高灵敏度和特异性 用于诊断青光眼早期阶段的技术是 为了提高预防的机会， 最终发展为 这种疾病 需要改进的早期诊断技术。 诊断，因为目前的方法允许检测疾病 只是在一个相对先进的阶段。 一旦疾病 尽管有最好的医疗条件， 手术治疗，仍然有令人不安的高发病率 视力的丧失。 希望通过改善 早期诊断疾病的敏感性， 可以为受影响的个人制定适当的治疗方案， 在早期阶段，增加了保存的可能性， 在疾病的后续过程中的视力。