PERIPHERAL TESTS OF COLOR VISION IN THE EARLY DIAGNOSIS

早期诊断中色觉的外围测试

• 批准号: 3262943
• 负责人: WILLIAM M HART
• 金额: $ 12.73万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3262943
• 关键词: color blindness; color visions; early diagnosis; glaucoma; glaucoma test; human subject; noninvasive diagnosis; perimetry; visual fields

Our objective to develop non-invasive visual function tests to improve the detection and diagnosis of glaucoma at the earliest stages of the disease. The visual function tests being evaluated are measures of color perception outside of the usual areas for such tests. Rather than studying color vision at the center of the visual field, we are looking at color contrast and spectral sensitivity functions in more peripheral locations in the visual field. Color contrast perimetry involves the use of variably colored test lights produced by a microcomputer controlled color video device, while peripheral spectral sensitivity tests measure the sensitivity for detection of variably colored test lights in the presence of strongly color adapting surrounds. Prior study of color vision defects in patients with glaucoma have suggested that damage to the perception of blue/yellow color contrast may occur prior to the onset of glaucomatous damage detectable by conventional (perimetric) forms of testing. The specific aims of this proposal are: (1) To prospectively evaluate the sensitivity of extrafoveal tests of color vision for the detection of earliest glaucomatous visual field defects in a population of patients known to be at high risk; (2) To test the hypothesis that glaucomatous visual field defects detected by extrafoveal tests of color vision antedate the appearance of defects as mapped by conventional threshold static perimetry. Efforts to improve the sensitivity and specificity of techniques used to diagnose the earliest stages of glaucoma are being sought so as to improve the chances of preventing irreversible loss of vision in patients who ultimately develop the disease. There is a need for improved techniques of early diagnosis since current methods allow detection of the disease only at a relatively advance stage. Once the disease is established, and in spite of the best available medical and surgical therapy, there remains a disturbingly high incidence of inexorable loss of vision. It is hoped that by improving the sensitivity of early diagnosis of the disease, that appropriate therapy can be instituted for affected individuals at an earlier stage, increasing the likelihood of preservation of vision over the subsequent course of the disease.

我们的目标是开发非侵入性视觉功能测试以 尽快提高青光眼的发现和诊断水平 疾病的各个阶段。视觉功能测试是 评估的是不同于通常颜色感知的测量 进行此类测试的区域。而不是在学校研究颜色视觉 视野的中心，我们看到的是颜色对比 以及更多外围位置的光谱灵敏度功能 在视野中。色彩对比视野检查涉及到使用 由微型计算机产生的可变颜色的测试灯 受控彩色视频设备，同时外围光谱 敏感度测试用于测量检测 在存在强烈颜色的情况下可变颜色的测试灯 适应周围环境。儿童色觉缺陷的前期研究 青光眼患者认为，青光眼的损害 对蓝色/黄色对比度的感知可能发生在 青光眼损害的发病可通过常规检查发现 (周边)测试形式。这样做的具体目的是 建议包括： (1)前瞻性评价中心凹外引流的敏感性。 色觉检查在早期诊断中的应用 一组青光眼患者的视野缺陷 已知存在高风险； (2)检验青光眼视野的假设 黄斑外早期色觉检查发现的缺陷 用常规阈值映射缺陷的外观 静态视野检查。 努力提高检测的敏感性和特异性 用于诊断青光眼早期阶段的技术有 被寻求以提高预防的机会 患者最终发展为不可逆转的视力丧失 这种疾病。有必要改进早期的技术 诊断，因为目前的方法可以检测到这种疾病 只是在一个相对较高的阶段。一旦这种疾病 建立了，尽管有最好的可用的医疗和 手术治疗，发病率仍然高得令人不安 无法抗拒的失明。人们希望通过改进 早期诊断疾病的敏感性，即 可以对受影响的个人进行适当的治疗 在更早的阶段，增加了保存的可能性 在随后的疾病病程中视力下降。