ENDOTHELIAL-LYMPHOCYTE INTERACTIONS IN THE RETINA
ENDOTHELIAL-LYMPHOCYTE INTERACTIONS IN THE RETINA
批准号:
3264758
负责人:
REUBEN EISENSTEIN
金额:
$10.24万
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-04-01 至 1994-03-31
关键词:
cell cell interaction cell growth regulation cellular immunity eye disorder chemotherapy growth factor receptors growth inhibitors immunosuppression leukocyte activation /transformation lymphocyte proliferation monocyte retina disorder retinal pigment epithelium transforming growth factors vascular endothelium vitreous body
中文摘要
参与葡萄膜道免疫的白细胞
炎症必须附着并穿过内皮细胞才能到达
血管周围组织,在那里它们会引起疾病。当地的因素
调节眼内淋巴细胞反应,包括淋巴细胞抑制剂
玻璃体和血管周围的神经胶质细胞均有增殖。
细胞。血管内皮细胞生长的抑制因子已在
玻璃体,这被认为是正常的部分原因
玻璃体无血管,其中之一似乎是转化生长因子β。工作量很大
提示内皮细胞可以刺激淋巴细胞增殖和
过程抗原。该项目旨在分析
血管内皮细胞、淋巴细胞功能和抑制物
与世隔绝。它包括a)淋巴细胞抑制物的纯化,以及
确定其是否与内皮抑制物相同,b)确定
在淋巴细胞进入组织的过程处于什么状态时,
抑制物起作用的淋巴细胞的分化和增殖,c)
确定它是直接作用于淋巴细胞还是通过中介作用
通过刺激淋巴细胞的细胞,如单核细胞或内皮细胞
细胞,d)确定该因子在体内和体内是否有效
组织培养,e)确定淋巴细胞的哪些亚群
影响因素,f)确定纯化的内皮细胞抑制物
细胞生长也有类似的影响。长期目标是使用这些
计划可以抑制局部免疫反应发生的治疗方法
免疫介导性眼病。
英文摘要
The white blood cells which are involved in uveal tract immune-mediated
inflammation must adhere to and traverse endothelium to reach the
perivascular tissues, where they cause disease. Local factors which
modulate lymphocyte responses in eye, including inhibitors of lymphocyte
proliferation have been demonstrated in vitreous and in perivascular glial
cells. Inhibitors of endothelial cell growth have been demonstrated in
vitreous, which are believed to be partly responsible for the normal
avascularity of vitreous, one of these appears to be TGF beta. Much work
suggests endothelial cells can stimulate lymphocyte proliferation and
process antigen. This project aims at analyzing relationships between
endothelial cells, lymphocyte function, and the inhibitors previously
isolated. It includes a) purification of the lymphocyte inhibitors, and
determining if it is the same as the endothelial inhibitor, b) determining
at which state of the processes of lymphocyte entry into the tissue,
differentiation, and proliferation of lymphocytes the inhibitors works, c)
determining whether it is a direct effect on lymphocytes or is mediated
through cells which stimulate lymphocytes such as monocytes or endothelial
cells, d) determining whether the factor is effective in vivo as well as in
tissue culture, e) determining which subpopulations of lymphocytes the
factor affects, f) determining whether purified inhibitors of endothelial
cell growth have similar effects. The long-term objective is to use these
to plan treatments which can suppress the local immune response occurring
in immune-mediated ocular disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ENDOTHELIAL-LYMPHOCYTE INTERACTIONS IN THE RETINA
-
批准号:3264759
-
项目类别:
-
资助金额:$10.86万
-
财政年份:1990
-
负责人:REUBEN EISENSTEIN
-
依托单位:
ENDOTHELIAL-LYMPHOCYTE INTERACTIONS IN THE RETINA
-
批准号:3264760
-
项目类别:
-
资助金额:$11.71万
-
财政年份:1990
-
负责人:REUBEN EISENSTEIN
-
依托单位:
ENDOTHELIAL-LYMPHOCYTE INTERACTIONS IN THE RETINA
-
批准号:3264757
-
项目类别:
-
资助金额:$10.31万
-
财政年份:1990
-
负责人:REUBEN EISENSTEIN
-
依托单位:
BIOLOGY OF AORTIC GROUND SUBSTANCE
-
批准号:3339088
-
项目类别:
-
资助金额:$8.69万
-
财政年份:1982
-
负责人:REUBEN EISENSTEIN
-
依托单位:
海外基金