BIOLOGY OF AORTIC GROUND SUBSTANCE

主动脉基底物质的生物学

• 批准号: 3339088
• 负责人: REUBEN EISENSTEIN
• 金额: $ 8.69万
• 依托单位: SINAI SAMARITAN MEDICAL CENTER-MILWAUKEE
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3339088
• 关键词: analytical method; aorta; atherosclerosis; carbohydrate biosynthesis; cardiovascular pharmacology; chemical aggregate; extracellular matrix; growth inhibitors; hyperlipidemia; immunodiffusion; low density lipoprotein; mucopolysaccharides; platelet aggregation; protease inhibitor; proteoglycan; radionuclide double label; tissue /cell culture; vascular endothelium; vascular smooth muscle; very low density lipoprotein

The project aims at characterizing aortic proteoglycans, assessing their interactions with lipoproteins and effects on platelet aggregation. A second major aim is to isolate and characterize an aortic endothelial cell growth regulator.

该项目旨在表征主动脉蛋白聚糖，评估其 与脂蛋白的相互作用以及对血小板聚集的影响。 第二 主要目的是分离和表征主动脉内皮细胞生长 调节器

项目成果

Smooth muscle cells produce an inhibitor of endothelial cell growth.

平滑肌细胞产生内皮细胞生长抑制剂。

• DOI: 10.1161/01.atv.5.1.110
• 发表时间: 1985
• 期刊: Arteriosclerosis (Dallas, Tex.)
• 作者: Schumacher,BL;Grant,D;Eisenstein,R
• 通讯作者: Eisenstein,R

Effect of medroxyprogesterone and an aorta-derived cell growth inhibitor on B16 melanoma in mice.

安宫黄体酮和主动脉源性细胞生长抑制剂对小鼠 B16 黑色素瘤的影响。

• 发表时间: 1984
• 期刊: Journal of the National Cancer Institute
• 作者: Eisenstein,R;Schumacher,B;Hsiao,K;Eisenstein,N;Lemke,M;Anderson,T;Harper,E
• 通讯作者: Harper,E

Attachment of proteoglycans to collagen fibrils. Effect on human platelet aggregation.

蛋白多糖与胶原纤维的附着。

• 发表时间: 1981
• 期刊: Laboratory investigation; a journal of technical methods and pathology
• 作者: Ts'ao,C;Eisenstein,R
• 通讯作者: Eisenstein,R

Additive cytotoxicity of adriamycin and a naturally occurring growth inhibitor extracted from bovine aorta.

阿霉素和从牛主动脉提取的天然生长抑制剂的附加细胞毒性。

• DOI: 10.1007/bf00176820
• 发表时间: 1985
• 期刊: Investigational new drugs
• 影响因子: 3.4
• 作者: Haid,M;Cohen,J;Mazariegos,G;Murthy,S;Eisenstein,R;Travis,JD
• 通讯作者: Travis,JD

Immunologic studies of bovine aortic and cartilage proteoglycans.

牛主动脉和软骨蛋白多糖的免疫学研究。

• DOI: 10.1177/29.4.7019307
• 发表时间: 1981
• 期刊: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
• 作者: Mangkornkanok-Mark,M;Eisenstein,R;Bahu,RM
• 通讯作者: Bahu,RM