STOCHASTIC PROCESSES IN POPULATION GENETICS

群体遗传学中的随机过程

• 批准号: 3270278
• 负责人: Warren J. EWENS
• 金额: $ 3.41万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1974
• 资助国家: 美国
• 起止时间: 1974-04-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3270278
• 关键词: computer simulation; disease /disorder proneness /risk; endonuclease; genetic models; genotype; heterozygote; human population genetics; insulin dependent diabetes mellitus; linkage mapping; major histocompatibility complex; mathematical model; natural selections; plant population genetics; statistics /biometry

The main aim of this proposal is to continue research in the following four areas (i) theoretical aspects of ascertainment sampling, in particular the development of ascertainment-assumption-free methods for pedigrees, for continuous characters and in regression problems, and to apply the theory to the estimation of parameters of genetic diseases; (ii) developments associated with the sampling theory of selectively neutral alleles, in particular the theory concerning age-order of alleles: (iii) practical aspects of the concept of a "minimum viable population size", applied to zoo and similar small populations, focussing on both genetic and demographic concepts; (iv) further development of the theory of random functions, in particular as it relates to population genetics. Since the proposed research is theoretical rather than experimental, there is no experimental design in the usual laboratory sense. The strategy of the research is to confirm theoretical predictions using simulated and real data using standard statistical methods. Computing of both mathematical functions and simulated "data" will be used throughout.

本提案的主要目的是继续研究