STOCHASTIC PROCESSES IN POPULATION GENETICS

群体遗传学中的随机过程

• 批准号: 3270278
• 负责人: Warren J. EWENS
• 金额: $ 3.41万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1974
• 资助国家: 美国
• 起止时间: 1974-04-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3270278
• 关键词: computer simulation; disease /disorder proneness /risk; endonuclease; genetic models; genotype; heterozygote; human population genetics; insulin dependent diabetes mellitus; linkage mapping; major histocompatibility complex; mathematical model; natural selections; plant population genetics; statistics /biometry

The main aim of this proposal is to continue research in the following four areas (i) theoretical aspects of ascertainment sampling, in particular the development of ascertainment-assumption-free methods for pedigrees, for continuous characters and in regression problems, and to apply the theory to the estimation of parameters of genetic diseases; (ii) developments associated with the sampling theory of selectively neutral alleles, in particular the theory concerning age-order of alleles: (iii) practical aspects of the concept of a "minimum viable population size", applied to zoo and similar small populations, focussing on both genetic and demographic concepts; (iv) further development of the theory of random functions, in particular as it relates to population genetics. Since the proposed research is theoretical rather than experimental, there is no experimental design in the usual laboratory sense. The strategy of the research is to confirm theoretical predictions using simulated and real data using standard statistical methods. Computing of both mathematical functions and simulated "data" will be used throughout.

该提案的主要目的是继续研究 以下四个领域 (i) 确定抽样的理论方面，特别是 开发无确定假设方法 谱系，对于连续字符和回归问题， 并将该理论应用于遗传参数的估计 疾病； (ii) 与抽样理论相关的发展 选择性中性等位基因，特别是有关的理论 等位基因的年龄顺序： (三) "最低可行方案"概念的实际方面 种群规模”，适用于动物园和类似的小种群， 关注遗传和人口概念； (iv) 随机函数理论的进一步发展， 特别是因为它与群体遗传学有关。 由于所提出的研究是理论性的而不是 实验性的，通常没有实验设计 实验室感觉。 研究策略是确认 使用模拟和实际数据进行理论预测 标准统计方法。 数学计算 函数和模拟“数据”将贯穿始终。