STOCHASTIC PROCESSES IN POPULATION GENETICS

群体遗传学中的随机过程

• 批准号: 2444454
• 负责人: Warren J. EWENS
• 金额: $ 4.64万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1974
• 资助国家: 美国
• 起止时间: 1974-04-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2444454
• 关键词: computer simulation; genetic models; human data; human population genetics; in situ hybridization; insulin dependent diabetes mellitus; linkage mapping; major histocompatibility complex; mathematical model; model design /development; natural selections; statistics /biometry

The broad aim of the proposed research is to attack theoretical questions arising in various practical disease-related issues, especially in connection with linkage analysis (of putative disease loci to markers), ascertainment corrections (usually associated with disease data) and the physical mapping of gene loci using anchored clones. Some specific aims of the proposed research are: (i) To continue work on the transmission distortion test (TDT) described elsewhere in this proposal. The TDT tests for linkage between marker and disease loci, and was developed to analyse data from presently or recently stratified populations. (ii) To continue research on the very difficult theory of ascertainment sampling where the data were collected by an ascertainment procedure on one variable (e.g. blood pressure) but the analysis considers a second, correlated, variable- (e.g. serum cholesterol level). (iii) To continue research, using computer simulations,. on the statistical properties of genome mapping using anchored clones, especially in cases where complexities such as hotspots make 'an analytical approach very difficult. (iv) To initiate research on statistical tests for comparing two or more populations-with respect to genetical characteristics (for example to compare the heterozygosity of two populations using restriction endonuclease data). (v) To initiate research on the question of assessing, when several loci contribute towards a disease, how much of the total (genetic) contribution is accounted for by each locus, and what the inactive effects between the loci on their contributions are.

拟议研究的广泛目标是解决理论问题 各种实际疾病相关问题，特别是 与连锁分析（推定的疾病基因座与标记的连锁分析）有关， 确定校正（通常与疾病数据相关）和 使用锚定克隆的基因位点的物理作图。一些具体目标 拟议的研究包括： (i)继续进行所述的传输失真测试（TDT） 在这个提案的其他地方。TDT测试标记与 疾病位点，并开发分析数据，从目前或 最近的人口结构。 (ii)继续研究非常困难的查明理论 通过确定程序收集数据的抽样 一个变量（例如血压），但分析考虑第二个变量， 相关的、可变的（例如血清胆固醇水平）。 (iii)为了继续研究，使用计算机模拟。对 使用锚定克隆的基因组作图的统计特性， 特别是在热点等复杂情况下， 分析方法很难。 (iv)为比较两个或多个数据而进行统计检验的研究 人口-关于遗传特征（例如， 用限制性内切酶比较两个群体的杂合性 核酸内切酶数据）。 (v)开始对评估问题的研究，当几个地点 导致疾病的因素，占总数的多少（遗传） 贡献是由每个位点占，什么是不活跃的 基因座对它们的贡献的影响是。