Development of a penside diagnostic test for Fasciola hepatica

肝片形吸虫的 Penside 诊断测试的开发

• 批准号: BB/T016981/1
• 负责人: Diana Williams
• 金额: $ 25.71万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FT016981%2F1
• 关键词: Development; penside; diagnostic; test; Fasciola

Fasciola hepatica, the common liver fluke, is a leading cause of mortality, morbidity and production losses in sheep and cattle in many of the major livestock rearing areas of the world. In highly endemic regions of the UK, because of the lack of cost effective diagnostic tests, groups of animals are blanket treated, which puts selection pressure on parasite populations to develop resistance. Resistance to drugs effective against liver fluke is becoming widespread. With funding from BBSRC, in partnership with all five UK meat and milk levy boards, we developed a preliminary prototype pen-side diagnostic test for F. hepatica, based on lateral flow technology. The aim of this project is to produce a validated pen-side lateral flow test for liver fluke, which works with a drop of blood collected from the ear of a cow or a sheep that farmers can use themselves, and that is ready to be taken up by a company for commercial development and production.

肝片吸虫是常见的肝吸虫，是世界上许多主要畜牧业地区绵羊和牛死亡、发病和产量损失的主要原因。在英国高度流行的地区，由于缺乏成本效益高的诊断测试，动物群被毯式治疗，这给寄生虫种群带来了选择压力，使其产生抗药性。对肝吸虫有效药物的耐药性正在变得普遍。在BBSRC的资助下，我们与英国所有五个肉类和牛奶征税委员会合作，开发了一个初步的笔侧诊断测试F。Hepatica，基于侧流技术。该项目的目的是生产一种经验证的笔侧侧流肝吸虫检测方法，该方法使用从牛或羊耳朵收集的一滴血，农民可以自己使用，并且准备由公司进行商业开发和生产。

项目成果

Update on liver fluke in sheep

绵羊肝吸虫的最新进展

• DOI: 10.1136/inp.m2398
• 发表时间: 2020
• 期刊: In Practice
• 影响因子: 0.3
• 作者: Williams D

Differences in the antibody response to adult Fasciola hepatica excretory/secretory products in experimentally and naturally infected cattle and sheep.

• DOI: 10.1016/j.vetpar.2020.109321
• 发表时间: 2021-01
• 期刊: Veterinary parasitology
• 影响因子: 2.6
• 作者: Walsh TR;Ainsworth S;Armstrong S;Hodgkinson J;Williams D
• 通讯作者: Williams D