From Peptides to Mimetics: Towards Smaller More Stable Drug-like Protein-protein Interaction Inhibitors

从肽到模拟物：走向更小、更稳定的药物样蛋白质-蛋白质相互作用抑制剂

• 批准号: BB/T018275/1
• 负责人: Jody Mason
• 金额: $ 6.29万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FT018275%2F1
• 关键词: Peptides; Mimetics; Towards; Smaller; More

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Correction: Twists or turns: stabilising alpha vs. beta turns in tetrapeptides

纠正：扭曲或转弯：稳定四肽中的 α 与 β 转弯

• DOI: 10.1039/d0sc90138e
• 发表时间: 2020
• 期刊: Chemical Science
• 影响因子: 8.4
• 作者: Hoang H

Single molecule imaging reveals the collective and independent search mechanisms of cFos and cJun on DNA

单分子成像揭示了cFos和cJun在DNA上集体且独立的搜索机制

• DOI: 10.1101/2020.01.24.918300
• 发表时间: 2020
• 作者: Leech J

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.

• DOI: 10.1186/s12943-020-01291-6
• 发表时间: 2021-01-04
• 期刊: Molecular cancer
• 影响因子: 37.3
• 作者: Madden SK;de Araujo AD;Gerhardt M;Fairlie DP;Mason JM
• 通讯作者: Mason JM

The effect of helix-inducing constraints and downsizing upon a transcription block survival-derived functional cJun antagonist.

• DOI: 10.1016/j.xcrp.2022.101077
• 发表时间: 2022-10-19
• 期刊: Cell reports. Physical science
• 作者: Brennan A;Leech JT;Kad NM;Mason JM
• 通讯作者: Mason JM

An Approach to Derive Functional Peptide Inhibitors of Transcription Factor Activity.

• DOI: 10.1021/jacsau.2c00105
• 发表时间: 2022-04-25
• 期刊: JACS AU
• 影响因子: 8
• 作者: Brennan, Andrew;Leech, James T;Kad, Neil M;Mason, Jody M
• 通讯作者: Mason, Jody M