CYCLIC PEPTIDES, STRUCTURE, AND FUNCTION

董事会和长期目标是研究公司的结构和 结晶态环肽的构象细节 使用X射线结晶学技术。许多生物活性 自然产生的物质，如激素、毒素、抗生素 和离子转运调节剂是或含有环肽 半个。天然多肽的合成类似物可以是 易合成及其构象和生物活性 学习。分子的构象与 它的生物活性。环状结构的构象研究 不同条件下结晶的多肽及其比较 与从其他方法获得的结果相比，细节可能非常详细 在确定生物活性构象方面有价值。这个过程 环化作用减少了可能的构象数量 可用于线性对应项。构象 环化作用对多肽几何构型的限制 环肽的优秀模型有助于更好地理解 调节多肽构象的基本原理和 蛋白质的基本构象性质。许多人 环状分子还与具有生物重要性的金属相互作用。 离子。这些服务器是更好地理解 离子在生物膜上的转移机理和 了解这些离子与多肽的相互作用 蛋白质。在本项目中，结构和结构的检查 几种有用的合成环肽的构象 利用x射线研究生物活性分子的类似物 结晶学技术已经计划好了。构象 这些研究获得的细节与 从光谱方法获得的信息可能会产生信息 关于多肽键的内部流动性。构象 信息可能对设计携带环肽有用 具有特定的生物功能，如离子载体、抗生素 或其他有用的药物。

The board and long term objective is to study the structure and conformation details of cyclic peptides in the crystalline state using x-ray crystallographic techniques. Many biologically active naturally occuring substances like hormones, toxins, antibiotics and ion transport regulators are or contain cyclic peptide moieties. Synthetic analogs of naturally occuring peptides can be easily synthesized and their conformation and biological activity studied. The conformation of a molecule is intimately related to its biological activity. The study of the conformation of cyclic peptides crystallized under different conditions and comparison of the details with those obtained from other methods could be very valuable in determining the bioactive conformation. The process of cyclization reduces the number of possible conformations available for the linear counterpart. The conformational restrictions imposed by cyclization on the peptide geometry make cyclic peptides excellent models for better understanding the basic principles that regulate peptide conformation and the fundamental conformational properties of proteins. Many of the cyclic molecules also interact with biologically important metal ions. These sever as good models for better understanding the mechanism of ion transfer across the biological membranes and understanding the interaction of these ions with peptides and proteins. In this project, the examination of the structure and conformation of a few synthetic cyclic peptides that are useful as analogs for biologically active molecules using x-ray crystallographic techniques is planned. The conformational details obtained by these studies when compared with those obtained from spectroscopic methods may yield information regarding internal mobility of peptide bond. The conformational information may be of use in designing cyclic peptides to carry out specific biological functions such as ions carriers, antibiotics or other useful drugs.