Developmental Patterning of the Anterior Neural Plate in a Simple Chordate
简单脊索动物前神经板的发育模式
基本信息
- 批准号:10338051
- 负责人:
- 金额:$ 35.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2023-01-31
- 项目状态:已结题
- 来源:
- 关键词:Afferent NeuronsAnteriorApicalCartilageCell LineageCell physiologyCellsCephalicChordataCiona intestinalisComplexDefectDevelopmentDorsalEctodermEmbryoEvolutionFundingFutureGNRH1 geneGenesGoalsHair CellsHeadHypothalamic structureIndividualInvertebratesLightMethodsModelingNeural CrestNeural tubeNeuronsPatternPigmentsPrenatal DiagnosisProcessPropertyRNAResearchSensorySourceSpecial sense organSpinal GangliaSuggestionSystemTadpolesTailUrochordataVertebratescell typecraniofacial boneembryo cellembryo tissuegene networkgene regulatory networkhuman diseaseinnovationinsightinterestmelanocytememberneural plateneuronal circuitryotoconiastem
项目摘要
PROJECT SUMMARY
The sea squirt Ciona intestinalis is member of the urochordates, the closest living relatives of the
vertebrates. Ciona tadpoles provide a favorable system for studying the evolutionary origins of
key vertebrate innovations such as cranial placodes and neural crest. There are four major
sensory cell types that arise from the neural plate border, which is the source of placodes and
neural crest in vertebrates. The Ciona system is ideally suited to elucidate the gene networks and
developmental mechanisms underlying the specification of all four sensory cell types: hair cells
(head), GnRH-expressing aATENs (trunk), pATENs and BTNs (tail). The detailed understanding
of these cell types should provide new insights into the evolutionary origins and developmental
mechanisms underlying the specification of comparable cell types derived from placodes and
neural crest in vertebrates, particularly placodes. During the preceding funding period we
obtained evidence that the hair cells and aATENs arise from a proto-placodal territory straddling
the anterior border of the presumptive neural tube. The aATENs possess dual chemosensory and
neurosecretory properties, suggesting they represent an ancestral cell type that produced
specialized cell types through a process of “cellular subfunctionalization” during the evolution of
the vertebrates. The pATENs and BTNs possess similarities with derivatives of the neural crest
in vertebrates, such as dorsal root ganglia. There are two over-arching goals of the proposed
study: (i) explore the specification, differentiation, and relatedness of hair cells, aATENs,
pATENs, and BTNs in the Ciona tadpole; and, (ii) explore the process of cellular
subfunctionalization, whereby ancestral sensory cell types in Ciona produce multiple specialized
cell types forming neuronal circuits in vertebrates.
项目总结
海鞘是尾索动物的一员,是海鞘最接近的近亲。
脊椎动物。乔纳蝌蚪为研究长臂猿的进化起源提供了一个良好的系统
脊椎动物的关键创新,如颅骨安慰剂和神经脊。有四个主要的
来自神经板边界的感觉细胞类型,这是安慰剂和
脊椎动物的神经脊。Ciona系统非常适合于阐明基因网络和
四种感觉细胞类型的发育机制:毛细胞
(头部)、表达GnRH的aATEN(躯干)、Patens和BTN(尾部)。详细的理解
这些类型的细胞应该为进化起源和发育提供新的见解
从安慰剂和安慰剂衍生的可比细胞类型规范的基础机制
脊椎动物的神经脊,尤指安慰剂。在之前的资助期内,我们
获得的证据表明,毛细胞和aATEN起源于横跨的原胎盘区域
假定神经管的前缘。AATEN具有双重化学感受性和
神经分泌特性,表明它们代表了一种祖先细胞类型,
细胞亚功能化过程中的特化细胞类型
脊椎动物。Patens和BTN与神经脊的导数有相似之处
脊椎动物,如背根神经节。拟议中的目标有两个
研究:(I)探索毛细胞的规格、分化和相关性,aATEN,
Patens和BTN;以及,(Ii)探索细胞的过程
亚功能化,在Ciona中,祖先的感觉细胞类型产生了多个专门的
脊椎动物中形成神经元回路的细胞类型。
项目成果
期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Shared evolutionary origin of vertebrate neural crest and cranial placodes.
脊椎动物神经rest和颅骨位置的共同进化起源。
- DOI:10.1038/s41586-018-0385-7
- 发表时间:2018-08
- 期刊:
- 影响因子:64.8
- 作者:Horie R;Hazbun A;Chen K;Cao C;Levine M;Horie T
- 通讯作者:Horie T
The hypothalamus predates the origin of vertebrates.
- DOI:10.1126/sciadv.abf7452
- 发表时间:2021-04
- 期刊:
- 影响因子:13.6
- 作者:Lemaire LA;Cao C;Yoon PH;Long J;Levine M
- 通讯作者:Levine M
FGF signaling establishes the anterior border of the Ciona neural tube.
FGF 信号传导建立 Ciona 神经管的前缘。
- DOI:10.1242/dev.078485
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Wagner,Eileen;Levine,Michael
- 通讯作者:Levine,Michael
Early chordate origins of the vertebrate second heart field.
- DOI:10.1126/science.1190181
- 发表时间:2010-07-30
- 期刊:
- 影响因子:0
- 作者:Stolfi A;Gainous TB;Young JJ;Mori A;Levine M;Christiaen L
- 通讯作者:Christiaen L
Depletion of Maternal Cyclin B3 Contributes to Zygotic Genome Activation in the Ciona Embryo.
- DOI:10.1016/j.cub.2018.02.046
- 发表时间:2018-04-02
- 期刊:
- 影响因子:0
- 作者:Treen N;Heist T;Wang W;Levine M
- 通讯作者:Levine M
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Michael Steven Levine其他文献
Michael Steven Levine的其他文献
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{{ truncateString('Michael Steven Levine', 18)}}的其他基金
Visualization of gene activity in the Drosophila embryo
果蝇胚胎中基因活性的可视化
- 批准号:
9981755 - 财政年份:2016
- 资助金额:
$ 35.15万 - 项目类别:
Visualization of gene activity in the Drosophila embryo
果蝇胚胎中基因活性的可视化
- 批准号:
10672202 - 财政年份:2016
- 资助金额:
$ 35.15万 - 项目类别:
Visualization of gene activity in the Drosophila embryo
果蝇胚胎中基因活性的可视化
- 批准号:
9767229 - 财政年份:2016
- 资助金额:
$ 35.15万 - 项目类别:
Visualization of gene activity in the Drosophila embryo
果蝇胚胎中基因活性的可视化
- 批准号:
10445268 - 财政年份:2016
- 资助金额:
$ 35.15万 - 项目类别:
Developmental patterning of the anterior neural plate in a simple chordate
简单脊索动物前神经板的发育模式
- 批准号:
8534308 - 财政年份:2012
- 资助金额:
$ 35.15万 - 项目类别:
Developmental patterning of the anterior neural plate in a simple chordate
简单脊索动物前神经板的发育模式
- 批准号:
8664456 - 财政年份:2012
- 资助金额:
$ 35.15万 - 项目类别:
Developmental patterning of the anterior neural plate in a simple chordate
简单脊索动物前神经板的发育模式
- 批准号:
8438221 - 财政年份:2012
- 资助金额:
$ 35.15万 - 项目类别:
Developmental patterning of the anterior neural plate in a simple chordate
简单脊索动物前神经板的发育模式
- 批准号:
8845622 - 财政年份:2012
- 资助金额:
$ 35.15万 - 项目类别:
Developmental patterning of the anterior neural plate in a simple chordate
简单脊索动物前神经板的发育模式
- 批准号:
9069633 - 财政年份:2012
- 资助金额:
$ 35.15万 - 项目类别:
Developmental patterning of the anterior neural plate in a simple chordate
简单脊索动物前神经板的发育模式
- 批准号:
9888443 - 财政年份:2012
- 资助金额:
$ 35.15万 - 项目类别:
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