Cardiac a1-adrenergic receptors in survival of the fittest

心脏α1-肾上腺素受体在适者生存中的作用

• 批准号: DP170104720
• 负责人: Prof Robert Graham
• 金额: $ 25.65万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170104720
• 关键词: Cardiac; a1; adrenergic; receptors; survival

This project aims to determine the role of alpha1A-adrenergic receptor inactivation, a receptor/signalling pathway, in mediating cardiac contraction and survival in response to stressors fight-or-flight response triggers.Higher organisms’ ability to respond to environmental changes is central to the survival of the fittest, and is mediated by the release of catecholamines that stimulate adrenergic receptors. The precise receptor and signalling pathways underlying these adaptive responses remain unclear. This project’s research could improve contractility, reduce cardiomyocyte death and define organismal adaptation to extreme environmental changes.

本项目旨在确定α α -肾上腺素能受体失活（一种受体/信号通路）在应激源或战或逃反应触发下介导心脏收缩和存活中的作用。高等生物对环境变化的反应能力是适者生存的核心，它是由儿茶酚胺的释放介导的，儿茶酚胺刺激肾上腺素能受体。这些适应性反应背后的确切受体和信号通路尚不清楚。该项目的研究可以提高收缩力，减少心肌细胞死亡，并确定对极端环境变化的有机体适应。