Allosteric regulation, molecular structure and function of transglutaminase 2

随着澳大利亚人口的老龄化，我们可以预期癌症、阿尔茨海默病和白内障等疾病的患病率将越来越高。普遍存在的谷氨酰胺转酶2 （TG2）与所有这些与年龄相关的疾病，以及乳糜泻和糖尿病等慢性疾病有关，并可能以积极的方式促进伤口愈合。了解TG2如何激活和失活，以及它如何选择靶点，将是对该酶现有知识的重要补充，也是开发TG2靶向药物和其他TG2相关疗法的必要前提。

With Australia's ageing population, we can expect to see increasing prevalence of pathologies such as cancer, Alzheimer's disease, and cataracts. The ubiquitous enzyme transglutaminase 2 (TG2) has been implicated in all of these age-related diseases, as well as in chronic disorders such as coeliac disease and diabetes, and may contribute in a positive way to wound healing. Understanding how TG2 is activated and inactivated, and how it selects its targets, will be a critical addition to current knowledge of this enzyme, and will be an essential prerequisite for the development of TG2-targetted drugs and other TG2-related therapies.