Allosteric regulation, molecular structure and function of transglutaminase 2

转谷氨酰胺酶2的变构调节、分子结构和功能

• 批准号: DP0665422
• 负责人: Prof Robert Graham
• 金额: $ 13.16万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0665422
• 关键词: Allosteric; regulation; molecular; structure; function

With Australia's ageing population, we can expect to see increasing prevalence of pathologies such as cancer, Alzheimer's disease, and cataracts. The ubiquitous enzyme transglutaminase 2 (TG2) has been implicated in all of these age-related diseases, as well as in chronic disorders such as coeliac disease and diabetes, and may contribute in a positive way to wound healing. Understanding how TG2 is activated and inactivated, and how it selects its targets, will be a critical addition to current knowledge of this enzyme, and will be an essential prerequisite for the development of TG2-targetted drugs and other TG2-related therapies.

随着澳大利亚人口的老龄化，我们可以预期癌症、阿尔茨海默病和白内障等疾病的患病率会越来越高。 普遍存在的酶转氨酶2（TG 2）与所有这些年龄相关的疾病以及慢性疾病如乳糜泻和糖尿病有关，并且可能以积极的方式促进伤口愈合。 了解TG2是如何激活和失活的，以及它如何选择其靶点，将是对这种酶的现有知识的重要补充，也将是开发TG2靶向药物和其他TG2相关疗法的必要先决条件。