UK International coronavirus network (UK-ICN)

这项建议是为了建立一个英国和国际网络(英国国际冠状病毒网络UK-ICN)，以了解冠状病毒对人和动物的感染情况，并促进不同科学学科的研究人员之间的联系。动物冠状病毒在许多国家造成了非常严重的疾病负担和巨大的经济损失。多年来，已经制定了各种战略来控制它们，包括具体的疫苗接种战略、诊断和改进的农场生物安全，但它们仍然是一个问题。此外，在过去20年里，我们看到出现了三种对人类健康造成毁灭性影响的冠状病毒--最近的SARS-CoV-2引发了一场全球大流行，迄今已导致200多万人死亡，破坏了生计，并造成了自第二次世界大战以来未曾见过的动荡。这三种致病人类冠状病毒都是从动物宿主那里溢出的，很可能来自蝙蝠，通过食物链进入人类种群。在英国这样一个研究密集的国家建立一个基础广泛的冠状病毒国际网络，将确保对动物和人类冠状病毒感兴趣的全球研究界能够迅速交流冠状病毒控制和治疗方面的经验教训。申请的一个优势是管理委员会。我们组建了一支管理团队，他们拥有广泛的专业知识，涵盖人类和动物冠状病毒、学术界、公共和兽医卫生。管理委员会的专门知识还包括将进入冠状病毒网络的其他病毒。促进这一广泛领域的讨论和交流意见的论坛至关重要；我们的网络将提供这些。此外，SARS-CoV-2大流行期间的旅行限制减少了初级科学家的网络机会，他们将成为未来的领导者。该网络的部分目标是帮助这些个人找到自己的伙伴关系，以确保冠状病毒研究牢牢地纳入科学和政策议程。正如人类和动物冠状病毒的传播所表明的那样，冠状病毒(和其他传染病)不尊重政治边界和民族国家，因此关于冠状病毒的网络不仅必须包括英国科学家，而且还必须具有国际影响力。

This proposal is for the establishment of a UK and international network (UK International coronavirus network UK-ICN) to understand coronavirus infections of humans and animals and promote links between researchers of different scientific disciplines. Animal coronaviruses cause a very significant disease burden and great economic loss in many countries. Over the years there have been various strategies developed to control them, including specific vaccination strategies, diagnostics and improved farm biosecurity, but they remain a problem. Furthermore, in the last two decades we have seen the emergence of three coronaviruses with devastating effects on human health - the most recent, SARS-CoV-2, has caused a global pandemic that has killed over 2 million people so far, destroyed livelihoods and caused a degree of upheaval not seen since World War 2. The three pathogenic human coronaviruses all spilled over from animal hosts and probably originated from bats, entering the human population through the food chain. Establishing a broad-based international network on coronaviruses centred in a research-intensive country like the UK will ensure that lessons in coronavirus control and treatment can be rapidly interchanged between the global research community interested in animal and human coronaviruses. A strength of the application is the management board. We have assembled a management team that has broad-ranging expertise across human and animal coronaviruses, academia, public and veterinary health. The expertise of the management board includes other viruses as well that will feed into the coronavirus network. Promoting discussion in this broad area and having fora for the exchange of ideas is vital; our network will provide these. In addition, travel restrictions during the SARS-CoV-2 pandemic have curtailed networking opportunities for the junior scientists who will be the leaders of the future. Part of the goal of this network is to facilitate these individuals finding their own partnerships to ensure that coronavirus research is firmly embedded in the scientific and policy agenda. As the spread of human and animal coronaviruses illustrates, coronaviruses (and other infectious diseases) do not respect political borders and nation states and therefore a network on coronaviruses has to encompass not only UK scientists but be international in reach as well.