Regulation of cyclin D1 in coronavirus infected cells

冠状病毒感染细胞中细胞周期蛋白 D1 的调节

• 批准号: BB/F019904/1
• 负责人: Julian Hiscox
• 金额: $ 47.96万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF019904%2F1
• 关键词: Regulation; cyclin; D1; coronavirus; infected

Viruses are one of the major causes of disease and can lead to significant economic loses in agriculture. Infectious bronchitis virus (IBV), the focus of this grant is no exception and the virus is reported to kill some 15,000,000 poultry annually with associated economic impact. Previous research suggests that many viruses can exploit the cells they infect to help in the growth and production of new viruses. As a result of previous BBSRC funding we have found that IBV also hijacks the host cell to fine tune its infectious cycle. One of the ways it does this is to manipulate what is called the cell cycle by interfering with the very molecules that control this vital cellular pathway. The cell cycle is a mechanism by which normal cells control their growth and production of new cells. The focus of this research proposal is to investigate how IBV interferes with the cell cycle by identify the virus protein(s) responsible and determining the precise mechanism involved. By doing this we aim to develop an in depth understanding of this process that will have broad application to similar viruses and exploit these findings in the development of new vaccines to aid in the control of IBV.

病毒是引起病害的主要原因之一，可导致农业重大经济损失。传染性支气管炎病毒（IBV），这一赠款的重点也不例外，据报道，该病毒每年杀死约1500万只家禽，并产生相关的经济影响。先前的研究表明，许多病毒可以利用它们感染的细胞来帮助新病毒的生长和生产。由于之前BBSRC的资助，我们发现IBV还劫持宿主细胞来微调其感染周期。它做到这一点的方法之一是通过干扰控制这一重要细胞途径的分子来操纵所谓的细胞周期。细胞周期是正常细胞控制其生长和产生新细胞的机制。这项研究计划的重点是通过鉴定负责的病毒蛋白质并确定所涉及的精确机制来研究IBV如何干扰细胞周期。通过这样做，我们的目标是深入了解这一过程，这将广泛应用于类似的病毒，并利用这些发现开发新的疫苗，以帮助控制IBV。