SYNTHESES OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES

不寻常的生物活性萜烯的合成

• 批准号: 3278721
• 负责人: LEO A PAQUETTE
• 金额: $ 16万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3278721
• 关键词: antibiotics; antifungal agents; antileukemic agent; antineoplastics; beta lactam antibiotic; diterpenes; drug design /synthesis /production; drug metabolism; sesquiterpenes; terpenes; tumor promoters

Protocols are offered by which ongoing synthetic efforts should culminate in the acquisition of: (a) pleuromutilin, a diterpene antibiotic produced by several basidiomycetes; (b) sterpuric acid, a sesquiterpenoid metabolite of the fungus Stereum purpureum; and (c) 3Beta-hydroxy-7Beta-kemp-8(9)-en-6-one, a cembrene-derived diterpene produced by nasute termite soldiers. In addition, new efforts are outlined for the purpose of developing new methodologies that will culminate in the laboratory preparation of: (d) acetoxycrenulide, a unique bicyclic cyclopropane-containing diterpenoid exuded by small brown phaeophyta; (e) 7,8-epoxy-4-basmen-6-one, a tricyclic diterpenoid of unusual structure produced by certain types of Oriental tobacco; (f) jatrophatrione, a tricyclic triketo diterpene possessing a 5/9/5-fused ring skeleton that exhibits good inhibitory activity toward the P-388 (3PS) lymphocytic leukemia test system; (g) neolemnanyl acetate, an irregular sesquiterpene produced by the Pacific soft coral Lemnalia africana; (h) cerorubenic acid-III, a kairomone secreted by Ceroplastes rubens recognized for its ability to control the ovipositional behavior of certain insects; and (i) punctatin A, a product of the dung fungus Poronia punctata that is reputed for its antibiotic activity.

议定书提供了正在进行的综合努力应达到高潮 收购：（a）截短侧耳素，一种生产的二萜抗生素 （B）甾醇酸，一种倍半萜类代谢物 真菌Stereum purpureum;和（c） 3Beta-hydroxy-7Beta-kemp-8（9）-en-6-one，a cembrene-derived di萜烯 由纳苏特白蚁士兵制造。 此外，还概述了新的努力 为了开发新的方法， 实验室制备：（d）乙酰氧基克瑞舒利，一种独特双环 由小型棕色褐藻分泌的含环丙烷的二萜类化合物;（e） 7，8-环氧-4-巴斯曼-6-酮，一种结构奇特的三环二萜 由某些类型的东方烟草产生;（f）麻黄素，a 具有5/9/5-稠环骨架的三环三酮基二萜， 对P-388（3 PS）淋巴细胞具有良好的抑制活性 白血病测试系统;（g）乙酸新莱曼酯，一种不规则倍半萜 由太平洋软珊瑚Lemnalia africana产生;（h）蜡鲁本 酸-III，一种由红蜡蚧分泌的利它素， 控制某些昆虫产卵行为的能力;及（i） punctatin A，粪菌Poronia punctata的产物， 因为它的抗生素活性。